Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HTR6 | P50406 | 11/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235673 | 1.00 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DGAA | |
| Hydrochloric Acid SCHEMBL6237229 | 0.99 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL6237285 | 0.99 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL6235886 | 0.90 | HTR6 (0.60) | HTR6 | |
| SCHEMBL6236589 | 0.89 | HTR6 (0.56) | HTR6 | |
| SCHEMBL6233388 | 0.87 | HTR6 (0.57) | HTR6 | |
| SCHEMBL6234179 | 0.86 | ALDH1A1 (0.60) | ALDH1A1HTR6TP53 | |
| SCHEMBL6235655 | 0.86 | HTR6 (0.63) | HTR6 | |
| SCHEMBL6234987 | 0.85 | HTR6 (0.58) | HTR6 | |
| SCHEMBL6238497 | 0.85 | HTR6 (0.58) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049679-B1 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | claimed |
| US-6548504-B1 | Compounds | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-04-15 | — | — | US | claimed |
| EP-1049679-A2 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-08 | — | — | EP | claimed |
| WO-1999037623-A2 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-29 | — | — | WO | claimed |
| EP-1049679-B1 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | disclosed |
| US-6548504-B1 | Compounds | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-04-15 | — | — | US | disclosed |
| EP-1049679-A2 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999037623-A2 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-29 | — | — | WO | disclosed |