SCHEMBL6234751

SCHEMBL6234751

O=C(OCc1cccnc1)c1ncccn1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.59
LMNA P02545 2/20 0.59
TDP1 Q9NUW8 1/20 0.59
CYP17A1 P05093 1/20 0.51
CYP19A1 P11511 1/20 0.51
ALDH1A1 P00352 5/20 0.51
POLB P06746 1/20 0.49
NAPRT Q6XQN6 1/20 0.49
MEN1 O00255 1/20 0.48
MAPT P10636 1/20 0.48
HTT P42858 1/20 0.48
RECQL P46063 1/20 0.47
HDAC1 Q13547 1/20 0.47
FAAH O00519 1/20 0.46
NAMPT P43490 1/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
TSHR P16473 1/20 0.46
CASP3 P42574 1/20 0.46
RAB9A P51151 1/20 0.46
SENP8 Q96LD8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7101474 0.83 POLB (0.62) KMT2ALMNATDP1ALDH1A1POLB
SCHEMBL290287 0.82 TDP1 (0.85) KMT2ALMNATDP1CYP17A1CYP19A1
SCHEMBL28711108 0.81 KMT2A (0.58) KMT2ALMNATDP1CYP17A1CYP19A1
SCHEMBL4245622 0.81 KMT2A (0.58) KMT2ALMNATDP1CYP17A1CYP19A1
SCHEMBL30335693 0.81 KMT2A (0.82) KMT2ALMNATDP1CYP17A1CYP19A1
SCHEMBL27597233 0.81 KMT2A (0.82) KMT2ALMNATDP1CYP17A1CYP19A1
SCHEMBL12230963 0.80 KMT2A (0.57) KMT2ALMNATDP1CYP17A1CYP19A1
SCHEMBL4245629 0.80 KMT2A (0.61) KMT2ALMNATDP1CYP17A1CYP19A1
SCHEMBL2519199 0.78 ALDH1A1 (0.61) KMT2ALMNATDP1CYP17A1CYP19A1
SCHEMBL4667872 0.78 KMT2A (0.55) KMT2ALMNATDP1CYP17A1CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1530467-A2 COMBINATION OF AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB Warner-Lambert Company LLC (US) 2005-05-18 EP disclosed
WO-2004006912-A2 COMBINATION OF AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed
EP-1370562-A1 THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS Warner-Lambert Company LLC (US) 2003-12-17 EP disclosed
WO-2002064598-A1 THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2002-08-22 WO disclosed