Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 3/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235648 | 0.90 | HRH3 (0.51) | HRH3KCNH2HRH1HRH2RAB9A | |
| SCHEMBL6255922 | 0.87 | HRH3 (0.51) | HRH3KCNH2HRH1HRH2RAB9A | |
| SCHEMBL6240919 | 0.80 | RPS6KB2 (0.44) | HRH3KCNH2RAB9ANPC1MAPK1 | |
| SCHEMBL6233813 | 0.80 | RPS6KB2 (0.43) | HRH3KCNH2RAB9ANPC1MAPK1 | |
| SCHEMBL6237806 | 0.80 | CHEK2 (0.40) | CXCR1 | |
| SCHEMBL6237136 | 0.79 | RPS6KB2 (0.44) | RAB9ANPC1MAPK1 | |
| SCHEMBL6233986 | 0.73 | ACP1 (0.39) | HRH3KCNH2 | |
| SCHEMBL6234523 | 0.72 | CYP1A2 (0.42) | MAPK1 | |
| SCHEMBL6240032 | 0.72 | RPS6KB2 (0.42) | HRH3KCNH2RAB9ANPC1MAPK1 | |
| SCHEMBL6236199 | 0.71 | RPS6KB2 (0.41) | HRH3KCNH2RAB9ANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |