Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233813 | 0.81 | RPS6KB2 (0.43) | RPS6KB2HRH3KCNH2 | |
| SCHEMBL6240919 | 0.79 | RPS6KB2 (0.44) | RPS6KB2HRH3KCNH2 | |
| SCHEMBL6237136 | 0.78 | RPS6KB2 (0.44) | RPS6KB2CHEK2 | |
| SCHEMBL6255922 | 0.75 | HRH3 (0.51) | SLC6A4HRH3KCNH2 | |
| SCHEMBL6235648 | 0.75 | HRH3 (0.51) | HRH3KCNH2 | |
| SCHEMBL6234869 | 0.73 | HRH3 (0.48) | HRH3KCNH2 | |
| SCHEMBL6240032 | 0.72 | RPS6KB2 (0.42) | RPS6KB2HRH3KCNH2 | |
| SCHEMBL6236199 | 0.71 | RPS6KB2 (0.41) | RPS6KB2HRH3KCNH2 | |
| SCHEMBL6237798 | 0.71 | RPS6KB2 (0.52) | RPS6KB2 | |
| SCHEMBL6237105 | 0.71 | RPS6KB2 (0.49) | RPS6KB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |