SCHEMBL6234889

SCHEMBL6234889

COc1ccc(CC2SC(=O)NC2=O)cc1CC(=O)Nc1ccc(C(F)(F)F)cc1

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 2/20 0.58
PPARG P37231 2/20 0.50
KCNH2 Q12809 1/20 0.49
CACNA1C Q13936 1/20 0.49
SCN5A Q14524 1/20 0.49
PTPN1 P18031 2/20 0.49
MAPT P10636 4/20 0.48
LMNA P02545 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
TP53 P04637 1/20 0.46
FFAR1 O14842 3/20 0.45
CA2 P00918 1/20 0.44
CSNK1D P48730 1/20 0.43
HTT P42858 1/20 0.43
PPARD Q03181 1/20 0.42
GAA P10253 1/20 0.42
RAB9A P51151 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6232906 0.85 PPARA (0.57) PPARAPPARGKCNH2CACNA1CSCN5A
SCHEMBL6232136 0.85 MAPT (0.52) PPARGPTPN1MAPTLMNAFFAR1
SCHEMBL6506168 0.84 PPARD (0.61) PPARAPPARGPTPN1PPARD
SCHEMBL6231586 0.84 PPARG (0.51) PPARAPPARGPTPN1MAPTLMNA
SCHEMBL6497355 0.82 PPARG (0.54) PPARAPPARGPTPN1MAPTSMN1; SMN2
SCHEMBL6498084 0.80 FFAR1 (0.56) PPARAPPARGPTPN1MAPTTP53
SCHEMBL6502439 0.80 PPARD (0.61) PPARAPPARGPTPN1PPARD
SCHEMBL20125593 0.80 PPARA (0.61) PPARAPPARGPTPN1PPARD
SCHEMBL14379043 0.80 PPARA (0.61) PPARAPPARGPTPN1PPARD
SCHEMBL3922 0.80 PPARA (0.61) PPARAPPARGPTPN1PPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1213287-B1 SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES KYORIN SEIYAKU KK (JP) 2005-05-25 EP claimed
US-6730687-B1 THERAPY OF METABOLIC DISEASES SUCH AS DIABETES AND HYPERLIPIDEMIA AS AGONISTS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR KYORIN PHARMACEUTICAL CO., LTD. (JP) 2004-05-04 US claimed
EP-1213287-A1 SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES KYORIN PHARMACEUTICAL CO., LTD. (JP) 2002-06-12 EP claimed
EP-1213287-B1 SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES KYORIN SEIYAKU KK (JP) 2005-05-25 EP disclosed
US-6730687-B1 THERAPY OF METABOLIC DISEASES SUCH AS DIABETES AND HYPERLIPIDEMIA AS AGONISTS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR KYORIN PHARMACEUTICAL CO., LTD. (JP) 2004-05-04 US disclosed
EP-1213287-A1 SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES KYORIN PHARMACEUTICAL CO., LTD. (JP) 2002-06-12 EP disclosed