SCHEMBL6232906

SCHEMBL6232906

COc1ccc(CC2SC(=O)NC2=O)cc1NC(=O)Cc1ccc(C(F)(F)F)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 1/20 0.57
PPARG P37231 1/20 0.52
SMN1; SMN2 Q16637 2/20 0.51
TP53 P04637 1/20 0.51
MAPT P10636 1/20 0.51
PTPN1 P18031 2/20 0.51
MAPK8 P45983 1/20 0.47
MAPK10 P53779 1/20 0.47
KCNH2 Q12809 1/20 0.47
CACNA1C Q13936 1/20 0.47
SCN5A Q14524 1/20 0.47
FFAR1 O14842 3/20 0.47
CA2 P00918 1/20 0.43
LMNA P02545 3/20 0.42
ALDH1A1 P00352 2/20 0.42
POLB P06746 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
HTT P42858 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6231586 0.88 PPARG (0.51) PPARAPPARGSMN1; SMN2TP53MAPT
SCHEMBL6236094 0.87 MEN1 (0.55) PPARGSMN1; SMN2TP53MAPTPTPN1
SCHEMBL6234889 0.85 PPARA (0.58) PPARAPPARGSMN1; SMN2TP53MAPT
SCHEMBL14379043 0.79 PPARA (0.61) PPARAPPARGPTPN1
SCHEMBL3922 0.79 PPARA (0.61) PPARAPPARGPTPN1
SCHEMBL29358494 0.79 PPARA (0.61) PPARAPPARGPTPN1
SCHEMBL20125593 0.79 PPARA (0.61) PPARAPPARGPTPN1
SCHEMBL6506168 0.79 PPARD (0.61) PPARAPPARGPTPN1
SCHEMBL6232308 0.78 PPARG (0.56) PPARAPPARGSMN1; SMN2TP53MAPT
SCHEMBL6497355 0.78 PPARG (0.54) PPARAPPARGSMN1; SMN2TP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1213287-B1 SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES KYORIN SEIYAKU KK (JP) 2005-05-25 EP claimed
US-6730687-B1 THERAPY OF METABOLIC DISEASES SUCH AS DIABETES AND HYPERLIPIDEMIA AS AGONISTS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR KYORIN PHARMACEUTICAL CO., LTD. (JP) 2004-05-04 US claimed
EP-1213287-A1 SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES KYORIN PHARMACEUTICAL CO., LTD. (JP) 2002-06-12 EP claimed
EP-1213287-B1 SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES KYORIN SEIYAKU KK (JP) 2005-05-25 EP disclosed
US-6730687-B1 THERAPY OF METABOLIC DISEASES SUCH AS DIABETES AND HYPERLIPIDEMIA AS AGONISTS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR KYORIN PHARMACEUTICAL CO., LTD. (JP) 2004-05-04 US disclosed
EP-1213287-A1 SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES KYORIN PHARMACEUTICAL CO., LTD. (JP) 2002-06-12 EP disclosed