Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | BCL9 | O00512 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GPR183 | P32249 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235843 | 0.86 | MEN1 (0.55) | MEN1KMT2ANPSR1GRIN2BTSHR | |
| SCHEMBL4678059 | 0.83 | DPP4 (0.55) | MEN1KMT2ANPSR1GRIN2BNPC1 | |
| Hydrochloric Acid SCHEMBL4680856 | 0.82 | DPP4 (0.54) | MEN1KMT2ANPSR1GRIN2BNPC1 | |
| SCHEMBL6236015 | 0.78 | MEN1 (0.62) | MEN1KMT2ANPSR1TSHRENPP2 | |
| SCHEMBL1337663 | 0.78 | KMT2A (0.97) | MEN1KMT2ANPSR1GRIN2BNPC1 | |
| SCHEMBL14095609 | 0.78 | KMT2A (0.97) | MEN1KMT2ANPSR1GRIN2BNPC1 | |
| SCHEMBL6235265 | 0.77 | MEN1 (0.53) | MEN1KMT2ANPSR1GRIN2BNPC1 | |
| SCHEMBL542951 | 0.77 | ENPP2 (0.54) | MEN1KMT2ANPSR1NPC1MAPT | |
| SCHEMBL1314311 | 0.75 | MEN1 (0.71) | MEN1KMT2ANPSR1GRIN2BNPC1 | |
| Hydrochloric Acid SCHEMBL1313138 | 0.74 | MEN1 (0.69) | MEN1KMT2ANPSR1GRIN2BNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390034-A4 | N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-1390034-A1 | N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002080928-A1 | N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2002-10-17 | — | — | WO | disclosed |