Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.48 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.48 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233041 | 0.88 | FYN (0.62) | DHODHMAPTNPC1PIK3CDPIK3CA | |
| SCHEMBL6257855 | 0.85 | DHODH (0.58) | DHODHMAPTNPC1PIK3CDPIK3CA | |
| SCHEMBL6235084 | 0.85 | KIF11 (0.67) | DHODHMAPTNPC1PIK3CDPIK3CA | |
| SCHEMBL6235521 | 0.84 | DHODH (0.57) | DHODHMAPTNPC1PIK3CDPIK3CA | |
| SCHEMBL6235785 | 0.84 | TP53 (0.62) | DHODHMAPTNPC1PIK3CDPIK3CA | |
| SCHEMBL6239029 | 0.80 | BAZ2B (0.64) | DHODHNPC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL6243512 | 0.77 | DHODH (0.54) | DHODHPIK3CDPIK3CAPIK3CGFYN | |
| SCHEMBL2632866 | 0.77 | MAPT (0.73) | MAPTMAPK1MEN1KMT2AKDR | |
| SCHEMBL6236761 | 0.76 | DHODH (0.52) | DHODHPIK3CDPIK3CAPIK3CGFYN | |
| SCHEMBL5934519 | 0.75 | TRPV1 (0.56) | DHODHBRAFLCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |