Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.61 |
| ▸ | BRAF | P15056 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | KMO | O15229 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236761 | 0.85 | DHODH (0.52) | PIK3CDPIK3CAPIK3CGDHODHKDM1A | |
| SCHEMBL27702482 | 0.85 | KMO (0.53) | PIK3CDPIK3CAPIK3CGDHODHCNR2 | |
| SCHEMBL6237221 | 0.85 | DHODH (0.52) | PIK3CDPIK3CAPIK3CGDHODHKDM1A | |
| SCHEMBL6234378 | 0.83 | HPGDS (0.68) | PIK3CDPIK3CAPIK3CGDHODHKDM1A | |
| SCHEMBL5934471 | 0.83 | MEN1 (0.57) | KDRKDM4EPOLBMEN1KMT2A | |
| SCHEMBL6233524 | 0.82 | ITGB3 (0.53) | PIK3CDPIK3CAPIK3CGDHODHKDM1A | |
| SCHEMBL5934519 | 0.82 | TRPV1 (0.56) | BRAFKDRDHODH | |
| SCHEMBL23888875 | 0.81 | KIF11 (0.57) | PIK3CDPIK3CAPIK3CG | |
| SCHEMBL5934763 | 0.80 | TRPV1 (0.54) | BRAFKDRDHODH | |
| SCHEMBL6235301 | 0.80 | DHODH (0.58) | PIK3CDPIK3CAPIK3CGBRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |