SCHEMBL623541

SCHEMBL623541

Cc1cc(Oc2cnc(N)s2)ccc1C(=O)OO

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GCK P35557 5/20 0.37
ICAM1 P05362 2/20 0.35
SELE P16581 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
NNMT P40261 1/20 0.33
TSHR P16473 1/20 0.33
KDM4E B2RXH2 1/20 0.33
POLB P06746 1/20 0.33
KMT2A Q03164 1/20 0.33
RAB9A P51151 1/20 0.33
CSNK2A1 P68400 1/20 0.33
GABRP O00591 1/20 0.33
GABRD O14764 1/20 0.33
GABRA1 P14867 1/20 0.33
GABRB1 P18505 1/20 0.33
GABRG2 P18507 1/20 0.33
GABRB3 P28472 1/20 0.33
GABRA5 P31644 1/20 0.33
GABRA3 P34903 1/20 0.33
GABRA2 P47869 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11972293 0.90 GAA (0.40) GCKTSHRKDM4EKMT2ADRD1
SCHEMBL623312 0.80 GCK (0.38) GCKTSHRKDM4EKMT2ADRD1
SCHEMBL9071240 0.80 ALDH1A1 (0.39) TSHRKDM4EPOLBKMT2ARAB9A
SCHEMBL185090 0.79 ILK (0.38) GCKKDM4EKMT2ACGAS
SCHEMBL5149605 0.78 MAPT (0.42) ICAM1SELESMN1; SMN2TSHRKDM4E
SCHEMBL11972292 0.78 TP53 (0.44) GCKSMN1; SMN2TSHRKDM4EKMT2A
SCHEMBL11971906 0.77 ABL1 (0.42) GCKSMN1; SMN2KDM4EKMT2ACDK8
SCHEMBL11972318 0.77 ILK (0.38) GCKTSHRKDM4EKMT2ACGAS
SCHEMBL184607 0.75 MAPT (0.47) SMN1; SMN2KDM4EPOLBRAB9A
SCHEMBL12475998 0.74 TSHR (0.54) ICAM1SELESMN1; SMN2TSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012020357-A1 ACETAMIDE COMPOUNDS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION ADVINUS THERAPEUTICS LTD. (IN) 2012-02-16 WO disclosed