Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28072623 | 0.95 | CA4 (0.39) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL29098772 | 0.95 | CA4 (0.39) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL7924520 | 0.95 | CA4 (0.39) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL28090789 | 0.95 | CA4 (0.39) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL15662074 | 0.95 | CA4 (0.50) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL25396149 | 0.95 | CA4 (0.39) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL5140509 | 0.95 | CA4 (0.50) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL15662076 | 0.95 | CA4 (0.50) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL30997 | 0.94 | — | — | |
| Bicarbonate SCHEMBL6235909 | 0.94 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050090675-A1 | Process for preparing highly pure androstane 17-beta-carboxylic acids and 17-beta-carbothioic acid fluoromethyl esters thereof | S.N.I.F.F. ITALIA S.P.A. (IT) | 2005-04-28 | — | — | US | disclosed |
| EP-1526139-A1 | A process for preparing highly pure androstane 17-beta-carboxylic acids and androstane 17-beta-carbothioic acid fluoromethyl esters | S.N.I.F.F. Italia S.P.A. (IT) | 2005-04-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090675-A1 | Process for preparing highly pure androstane 17-beta-carboxylic acids and 17-beta-carbothioic acid fluoromethyl esters thereof | CYP17A1, HSD17B11, HSD17B7 | CA4 311/4885CA1 55/4885FAHD1 1074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.