Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 1.00 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 1.00 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.53 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.47 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL650322 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL2046433 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL3998225 | 1.00 | — | — | |
| Maleic Acid SCHEMBL613 | 1.00 | — | — | |
| Maleic Acid SCHEMBL20487516 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL2046432 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL2046430 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL6875 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL615 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL1331192 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 142 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421530-A1 | A NOVEL FORMULATION OF METAXALONE | Iceutica Pty Ltd. (AU) | 2012-02-29 | — | — | EP | claimed |
| EP-2421510-A1 | PRODUCTION OF ENCAPSULATED NANOPARTICLES AT COMMERCIAL SCALE | Iceutica Pty Ltd. (AU) | 2012-02-29 | — | — | EP | claimed |
| EP-2421509-A1 | PRODUCTION OF ENCAPSULATED NANOPARTICLES AT HIGH VOLUME FRACTIONS | Iceutica Pty Ltd. (AU) | 2012-02-29 | — | — | EP | claimed |
| EP-2421513-A1 | A NOVEL FORMULATION OF INDOMETHACIN | Iceutica Pty Ltd. (AU) | 2012-02-29 | — | — | EP | claimed |
| EP-2421512-A1 | A NOVEL FORMULATION OF NAPROXEN | Iceutica Pty Ltd. (AU) | 2012-02-29 | — | — | EP | claimed |
| EP-2421516-A1 | METHOD FOR IMPROVING THE DISSOLUTION PROFILE OF A BIOLOGICALLY ACTIVE MATERIAL | Iceutica Pty Ltd. (AU) | 2012-02-29 | — | — | EP | claimed |
| EP-2421540-A1 | A NOVEL FORMULATION OF MELOXICAM | Iceutica Pty Ltd. (AU) | 2012-02-29 | — | — | EP | claimed |
| EP-2421511-A1 | METHOD FOR THE PRODUCTION OF COMMERCIAL NANOPARTICLE AND MICROPARTICLE POWDERS | Iceutica Pty Ltd. (AU) | 2012-02-29 | — | — | EP | claimed |
| EP-2421525-A1 | A NOVEL FORMULATION OF DICLOFENAC | Iceutica Pty Ltd. (AU) | 2012-02-29 | — | — | EP | claimed |
| JP-2011514671-A | — | — | 2011-05-06 | — | — | JP | claimed |
| US-20110046268-A1 | Self-Filleting Die Attach Paste | WANG MINGHAI | 2011-02-24 | — | — | US | claimed |
| EP-2250227-A1 | SELF-FILLETING DIE ATTACH PASTE | Henkel AG & Co. KGaA (DE) | 2010-11-17 | — | — | EP | claimed |
| WO-2009105911-A1 | SELF-FILLETING DIE ATTACH PASTE | NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING COPORATION (US) | 2009-09-03 | — | — | WO | claimed |
| US-11891537-B2 | Triphenylphosphine-containing coatings with enhanced adhesion to unprimed surfaces | SHEBOYGAN PAINT COMPANY (US) | 2024-02-06 | — | — | US | disclosed |
| US-20230011640-A1 | METHODS FOR RECOVERING ORGANIC SALTS FROM INDUSTRIAL PROCESS STREAMS | CYTEC INDUSTRIES INC. (US) | 2023-01-12 | — | — | US | disclosed |
| CN-112521294-B | Quaternary ammonium salt type cationic polyaspartic acid ester and preparation method and application thereof | 万华化学集团股份有限公司 | 2022-11-08 | — | — | CN | disclosed |
| US-4247445-A | ROOM-TEMPERATURE VULCANIZABLE SILICONE RUBBER COMPRISING A POLYSILOXANE, CALCIUM CARBONATE, ACYLOXYSILANE, AND CATALYST | GENERAL ELECTRIC COMPANY (US) | 1981-01-27 | — | — | US | disclosed |
| US-4110349-A | Two-step method for the alkenylation of maleic anhydride and related compounds | THE LUBRIZOL CORPORATION (US) | 1978-08-29 | — | — | US | disclosed |
| US-4101602-A | COATINGS | THE GENERAL TIRE & RUBBER COMPANY (US) | 1978-07-18 | — | — | US | disclosed |
| US-4061845-A | PROTECTIVE OR DECORATIVE COATINGS FOR BONDERIZED STEEL | THE GENERAL TIRE & RUBBER COMPANY (US) | 1977-12-06 | — | — | US | disclosed |