Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 1.00 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 1.00 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.53 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.47 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL613 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL650322 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL2046430 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL2046432 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL20487516 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL4671405 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL1331192 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL8364461 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL623596 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL2046433 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108148443-B | Preparation method of aqueous self-dispersion nano organic pigment powder | 江南大学 | 2019-08-20 | — | — | CN | claimed |
| CN-108148443-A | Preparation method of aqueous self-dispersion nano organic pigment powder | 江南大学 | 2018-06-12 | — | — | CN | claimed |
| CN-102926224-A | Preparation method of pigment ink for inkjet printing of non-adhesive textile | UNIV JIANGNAN | 2013-02-13 | — | — | CN | claimed |
| CN-116867786-A | Novel maleates of triazolopyrazine derivatives, compositions, methods of use and methods of making the same | 瑷备恩有限公司 | 2023-10-10 | — | — | CN | disclosed |
| US-11225456-B2 | Process for the preparation of a mixture of chelating agents, mixture of chelating agents and methods of using them | KEMIRA OYJ (FI) | 2022-01-18 | — | — | US | disclosed |
| US-20200181063-A1 | Process for the Preparation of a Mixture of Chelating Agents, Mixture of Chelating Agents and Methods of Using Them | KEMIRA OYJ (FI) | 2020-06-11 | — | — | US | disclosed |
| EP-3645508-A1 | PROCESS FOR THE PREPARATION OF A MIXTURE OF CHELATING AGENTS, MIXTURE OF CHELATING AGENTS AND METHODS OF USING THEM | Kemira Oyj (FI) | 2020-05-06 | — | — | EP | disclosed |
| CN-108148443-B | Preparation method of aqueous self-dispersion nano organic pigment powder | 江南大学 | 2019-08-20 | — | — | CN | disclosed |
| WO-2019002685-A1 | PROCESS FOR THE PREPARATION OF A MIXTURE OF CHELATING AGENTS, MIXTURE OF CHELATING AGENTS AND METHODS OF USING THEM | KEMIRA OYJ (FI) | 2019-01-03 | — | — | WO | disclosed |
| CN-108148443-A | Preparation method of aqueous self-dispersion nano organic pigment powder | 江南大学 | 2018-06-12 | — | — | CN | disclosed |
| US-6001946-A | Curable silane-encapped compositions having improved performances | WITCO CORPORATION (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0733035-A1 | TRICYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015939-A1 | TRICYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1995-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200181063-A1 | Process for the Preparation of a Mixture of Chelating Agents, Mixture of Chelating Agents and Methods of Using Them | HDHD5, NISCH, DNAJC5 | TSHR 2475/4885TP53 4529/4885EGLN1 2899/4885 |
| US-11225456-B2 | Process for the preparation of a mixture of chelating agents, mixture of chelating agents and methods of using them | HDHD5, NISCH, DNAJC5 | TSHR 2475/4885TP53 4529/4885EGLN1 2899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.