Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CTSV | O60911 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSH | P09668 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | CTSC | P53634 | 1/20 | 0.42 |
| ▸ | CTSZ | Q9UBR2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | LIPC | P11150 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3136332 | 0.91 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DCYP2D6 | |
| SCHEMBL27611797 | 0.88 | CYP2D6 (0.48) | PDE4APDE4BPDE4CPDE4DCYP2D6 | |
| SCHEMBL3137716 | 0.86 | YTHDC1 (0.42) | PDE4APDE4BPDE4CPDE4DCYP2D6 | |
| SCHEMBL4917270 | 0.79 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DCYP2D6 | |
| SCHEMBL6259489 | 0.79 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL27611709 | 0.78 | CYP2D6 (0.49) | PDE4APDE4BPDE4CPDE4DCYP2D6 | |
| SCHEMBL3146103 | 0.77 | YTHDC1 (0.40) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3141335 | 0.77 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL3130876 | 0.76 | TLR7 (0.43) | PDE4APDE4BPDE4CPDE4DCYP2D6 | |
| SCHEMBL4477884 | 0.76 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1529049-A2 | DERIVATIVES OF 2-TRIFLUORMETHYL-6-AMINOPURINE AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004014913-A2 | DERIVATIVES OF 2-TRIFLUORMETHYL-6-AMINOPURINE AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-02-19 | — | — | WO | disclosed |