Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30754748 | 0.78 | MEN1 (0.42) | CDK4CDK2BRAFMEN1KMT2A | |
| SCHEMBL22543338 | 0.78 | MEN1 (0.42) | CDK4CDK2BRAFMEN1KMT2A | |
| SCHEMBL30041659 | 0.76 | EPHX2 (0.48) | CDK2SCN9AKDRABL1FLT1 | |
| SCHEMBL27456494 | 0.76 | MAPK10 (0.51) | CDK4CDK2BRAFMEN1KMT2A | |
| SCHEMBL6240725 | 0.75 | TDO2 (0.51) | BRAFKDRCYP3A4RIPK1 | |
| SCHEMBL31137106 | 0.74 | KDM4E (0.44) | SCN9A | |
| SCHEMBL6237657 | 0.74 | AURKA (0.57) | MEN1KMT2ATSHRCYP3A4 | |
| SCHEMBL5397901 | 0.72 | CDK2 (0.47) | CDK4CDK2BRAFMEN1KMT2A | |
| SCHEMBL30263685 | 0.72 | MPL (0.47) | CDK4CDK2SCN9AABL1FYN | |
| SCHEMBL11377225 | 0.71 | NPC1 (0.66) | MEN1KMT2ATSHRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |