Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.57 |
| ▸ | KIF11 | P52732 | 1/20 | 0.55 |
| ▸ | IDH2 | P48735 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30041659 | 0.80 | EPHX2 (0.48) | DHODH | |
| SCHEMBL4532117 | 0.78 | EGFR (0.50) | AURKAEGFRABCG2RAPGEF4 | |
| SCHEMBL544111 | 0.78 | MEN1 (0.50) | PTK6LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL394991 | 0.77 | KIF11 (0.70) | AURKAKIF11IDH2THRBLMNA | |
| SCHEMBL6231959 | 0.77 | RAPGEF4 (0.49) | AURKANFKB1GRM4RAPGEF4 | |
| SCHEMBL30754777 | 0.77 | LMNA (0.65) | AURKAKIF11IDH2THRBLMNA | |
| SCHEMBL31501743 | 0.77 | AURKA (0.72) | AURKAKIF11IDH2THRBLMNA | |
| SCHEMBL6663767 | 0.77 | AURKA (0.72) | AURKAKIF11IDH2THRBLMNA | |
| SCHEMBL4238979 | 0.76 | AURKA (0.67) | AURKAKIF11IDH2THRBLMNA | |
| SCHEMBL6240725 | 0.76 | TDO2 (0.51) | CYP3A4GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |