SCHEMBL6236401

SCHEMBL6236401

CCC(C)(c1cc(F)c(O)c(F)c1)c1cc(F)c(O)c(F)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.39
ESR2 Q92731 3/20 0.39
ALOX15 P16050 2/20 0.34
CYP2C19 P33261 1/20 0.34
MAPK1 P28482 1/20 0.34
HTT P42858 1/20 0.34
RIPK1 Q13546 8/20 0.34
TSHR P16473 2/20 0.33
HIF1A Q16665 2/20 0.33
HSD17B10 Q99714 2/20 0.33
PDE2A O00408 1/20 0.33
CYP2C9 P11712 1/20 0.33
AR P10275 1/20 0.32
VRK1 Q99986 1/20 0.32
ALDH1A1 P00352 1/20 0.31
CYP3A4 P08684 1/20 0.31
HPGD P15428 1/20 0.31
ALOX12 P18054 1/20 0.31
CASP1 P29466 1/20 0.31
RECQL P46063 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13918218 0.83 ESR1 (0.39) ESR1ESR2ALOX15CYP2C19MAPK1
SCHEMBL7937250 0.83 ALOX15 (0.34) ESR1ESR2ALOX15CYP2C19MAPK1
SCHEMBL5078050 0.78 ESR1 (0.46) ESR1ESR2ALOX15HSD17B10PDE2A
SCHEMBL14509354 0.78 ESR1 (0.35) ESR1ESR2ALOX15CYP2C19MAPK1
SCHEMBL226013 0.77 ESR1 (0.64) ESR1ESR2CYP2C19TSHRHIF1A
SCHEMBL4463634 0.77 ALOX15 (0.36) ESR1ESR2ALOX15CYP2C19MAPK1
SCHEMBL544725 0.77 ALOX15 (0.52) ESR1ESR2ALOX15CYP2C19MAPK1
SCHEMBL804619 0.77 GABRA1 (0.52) ALOX15CYP2C19MAPK1HTTTSHR
SCHEMBL1068555 0.74 HSD17B10 (0.42) ESR1ESR2ALOX15CYP2C19MAPK1
SCHEMBL1238197 0.74 TSHR (0.61) ESR1ESR2ALOX15CYP2C19TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9563139-B2 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2017-02-07 US disclosed
US-20160124328-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2016-05-05 US disclosed
EP-1274762-B1 POLYCARBONATE PREPARATION PROCESS DOW GLOBAL TECHNOLOGIES INC (US) 2005-05-11 EP disclosed
EP-1274762-A1 POLYCARBONATE PREPARATION PROCESS THE DOW CHEMICAL COMPANY (US) 2003-01-15 EP disclosed
WO-2001077204-A1 POLYCARBONATE PREPARATION PROCESS DOW GLOBAL TECHNOLOGIES INC. (US) 2001-10-18 WO disclosed
US-6258498-B1 POLYCARBONATE PROTECTIVE COATING CANON KABUSHIKI KAISHA (JP) 2001-07-10 US disclosed
US-6225436-B1 REACTING PHOSGENE AND DIHYDRIC PHENOL; ADDING ACYL HALIDE; ADDING A CHAIN TERMINATOR TO THE REACTION MIXTURE; COMPLETING POLYMERIZATION REACTION THE DOW CHEMICAL COMPANY 2001-05-01 US disclosed
EP-0941268-A1 POLYCARBONATES THE DOW CHEMICAL COMPANY (US) 1999-09-15 EP disclosed
WO-1998022522-A1 POLYCARBONATES THE DOW CHEMICAL COMPANY (US) 1998-05-28 WO disclosed
US-RE35499-E MOLDED ARTICLES SUCH AS COMPACT DISKS THE DOW CHEMICAL COMPANY (US) 1997-04-29 US disclosed
US-4210741-A Phenolphthalein-dihydroxy aromatic compound polycarbonates THE DOW CHEMICAL COMPANY (US) 1980-07-01 US disclosed
US-4195156-A ALKALI METAL SALTS OF DIHYDROXY- BENZENE MONO OR DI SULFONIC ACIDS AS COMONOMERS THE DOW CHEMICAL COMPANY (US) 1980-03-25 US disclosed
US-4168368-A STRESS RESISTANCE THE DOW CHEMICAL COMPANY (US) 1979-09-18 US disclosed
US-4156769-A Process for making polycarbonates using 1,1-dimethyl urea compounds as the catalysts THE DOW CHEMICAL COMPANY (US) 1979-05-29 US disclosed
US-4111910-A POLYCARBONATES HAVING CARBAMATE TERMINAL GROUPS THE DOW CHEMICAL COMPANY (US) 1978-09-05 US disclosed
US-4100139-A Polycarbonates incorporating epihalohydrin residues THE DOW CHEMICAL COMPANY (US) 1978-07-11 US disclosed
US-4059566-A Process for controlling the molecular weight of polycarbonates using ammonia or ammonia compounds THE DOW CHEMICAL COMPANY (US) 1977-11-22 US disclosed
US-4055544-A Process for making polycarbonates using ammonia or ammonia compounds as the catalysts THE DOW CHEMICAL COMPANY (US) 1977-10-25 US disclosed
US-4020045-A METALLIC SULFITES THE DOW CHEMICAL COMPANY (US) 1977-04-26 US disclosed
US-3992357-A THERMOPLASTIC THE DOW CHEMICAL COMPANY (US) 1976-11-16 US disclosed