Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.69 |
| ▸ | HTR6 | P50406 | 17/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6234448 | 0.99 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL6235655 | 0.84 | HTR6 (0.63) | HTR6 | |
| SCHEMBL7425456 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7418696 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13350317 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6237285 | 0.79 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL6234462 | 0.79 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL6235673 | 0.79 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL6235886 | 0.78 | HTR6 (0.60) | HTR6 | |
| Hydrochloric Acid SCHEMBL6237229 | 0.78 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049679-B1 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | claimed |
| EP-1049679-B1 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | disclosed |
| US-6548504-B1 | Compounds | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-04-15 | — | — | US | disclosed |