Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CTSC | P53634 | 2/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | IDH2 | P48735 | 2/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | CD38 | P28907 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696775 | 0.93 | RPS6KB2 (0.53) | MAPTTP53CTSCABCG2EGFR | |
| SCHEMBL6237490 | 0.84 | ABCG2 (0.67) | MAPTABCG2EGFRHTTMEN1 | |
| SCHEMBL7695845 | 0.82 | RPS6KB2 (0.57) | MAPTABCG2HTTMEN1KMT2A | |
| SCHEMBL6259663 | 0.82 | PDE5A (0.61) | MAPTTP53ABCG2HTTMEN1 | |
| SCHEMBL17432160 | 0.82 | ABCG2 (0.65) | MAPTTP53CTSCABCG2EGFR | |
| SCHEMBL6235369 | 0.81 | MEN1 (0.58) | MAPTABCG2EGFRHTTMEN1 | |
| SCHEMBL6236522 | 0.81 | ABCG2 (0.48) | MAPTABCG2EGFRHTTMEN1 | |
| SCHEMBL6239843 | 0.79 | ABCG2 (0.53) | MAPTABCG2EGFRHTTMEN1 | |
| SCHEMBL7691382 | 0.77 | ABCG2 (0.61) | MAPTABCG2EGFRHTTMEN1 | |
| SCHEMBL6239210 | 0.76 | MAPT (0.47) | MAPTTP53CTSCHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |