Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046542 | 0.89 | POLB (0.36) | TAS1R3TAS1R1CTSKTSHRPKM | |
| SCHEMBL4045236 | 0.88 | CTSK (0.47) | CTSKGPR132HTRA1 | |
| SCHEMBL4037490 | 0.86 | CTSK (0.48) | CTSKGPR132HTRA1NPC1RAB9A | |
| SCHEMBL4037811 | 0.86 | CTSK (0.57) | CTSKGPR132HTRA1MEN1NPC1 | |
| SCHEMBL4039803 | 0.86 | CTSK (0.49) | CTSKGPR132 | |
| SCHEMBL4039065 | 0.86 | CTSK (0.57) | CTSKCHRNB2CHRNA7CHRNA4GPR132 | |
| SCHEMBL4039388 | 0.86 | CTSK (0.45) | CTSKCHRNB2CHRNA7CHRNA4GPR132 | |
| SCHEMBL4038068 | 0.85 | CTSK (0.44) | CTSKGPR132 | |
| SCHEMBL4038144 | 0.85 | CTSK (0.45) | TAS1R3TAS1R1CTSKGPR132HTRA1 | |
| SCHEMBL4042871 | 0.84 | CTSK (0.48) | CTSKGPR132HTRA1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |