Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | BMP1 | P13497 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050084 | 0.93 | CTSK (0.41) | POLBBMP1MEN1USP2ALDH1A1 | |
| SCHEMBL4043031 | 0.89 | HTRA1 (0.37) | CTSKPAX8ACACBGPR132 | |
| SCHEMBL6236558 | 0.89 | TAS1R3 (0.45) | MEN1KMT2ATSHRPKMCTSK | |
| SCHEMBL4043650 | 0.88 | BMP1 (0.36) | POLBBMP1MEN1USP2ALDH1A1 | |
| SCHEMBL4047771 | 0.88 | CTSK (0.39) | CTSKACACBGPR132 | |
| SCHEMBL4044443 | 0.87 | ALDH1A1 (0.38) | ALDH1A1CTSKPAX8ACACBGPR132 | |
| SCHEMBL4040981 | 0.86 | CTSK (0.35) | ALDH1A1CTSKPAX8ACACBGPR132 | |
| SCHEMBL4050093 | 0.85 | HTT (0.41) | BMP1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL4045728 | 0.85 | CTSK (0.35) | ALDH1A1CTSKPAX8ACACBGPR132 | |
| SCHEMBL4041663 | 0.84 | CTSK (0.35) | MEN1USP2KMT2ATSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |