Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3885748 | 0.86 | S1PR4 (0.43) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL3151103 | 0.83 | ALDH1A1 (0.48) | ESR2PTGS2CA1CA2CA12 | |
| SCHEMBL776573 | 0.83 | PTPN1 (0.42) | PTGS2MMP1MMP2MMP3MMP7 | |
| SCHEMBL7510471 | 0.81 | CA12 (0.47) | PTGS2MMP2MMP7MMP14CA1 | |
| SCHEMBL11587247 | 0.81 | DHFR (0.46) | CA1CA2CA12CA9ALDH1A1 | |
| SCHEMBL11539342 | 0.80 | CA12 (0.42) | PTGS2CA1CA2CA12CA9 | |
| SCHEMBL16574007 | 0.79 | ESR2 (0.52) | ESR2ALDH1A1 | |
| SCHEMBL11324926 | 0.79 | ALDH1A1 (0.45) | PKMCA1CA2CA12ALDH1A1 | |
| SCHEMBL10574941 | 0.78 | FLT1 (0.47) | PKMPTGS2PTGS1 | |
| SCHEMBL309222 | 0.78 | ALDH1A1 (0.52) | ESR2PGRMMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009384-A2 | EGFR TYROSINE KINASE INHIBITORS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-02-03 | — | — | WO | disclosed |