Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | STAT6 | P42226 | 4/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.38 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.38 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.38 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.38 |
| ▸ | STK16 | O75716 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6279604 | 0.94 | PTK2 (0.40) | NTRK1PTK2PTK2BJAK2PRKD3 | |
| SCHEMBL6212141 | 0.93 | KDM4E (0.43) | NTRK1STAT6PTK2PTK2BCDK9 | |
| SCHEMBL6210924 | 0.88 | JAK2 (0.40) | PTK2PTK2BJAK2PRKD3MARK3 | |
| SCHEMBL6236688 | 0.88 | PTK2 (0.42) | NTRK1PTK2PTK2BJAK2PRKD3 | |
| SCHEMBL6239654 | 0.88 | CDK1 (0.44) | NTRK1PTK2JAK2PRKD3MARK3 | |
| SCHEMBL6241707 | 0.87 | KDM4E (0.43) | NTRK1PTK2PTK2BJAK2PRKD3 | |
| SCHEMBL6212597 | 0.87 | NTRK1 (0.49) | NTRK1PTK2CDK9 | |
| SCHEMBL6241718 | 0.86 | PRKCD (0.47) | NTRK1PTK2JAK2PRKD3MARK3 | |
| SCHEMBL6236216 | 0.86 | STK17B (0.42) | NTRK1PTK2JAK2PRKD3MARK3 | |
| SCHEMBL6210939 | 0.86 | HTR2C (0.42) | NTRK1PTK2JAK2PRKD3MARK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578732-A2 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056786-A2 | PYRIMIDINE DERIVATES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |