Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 14/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 14/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2754132 | 0.87 | NR1H2 (0.45) | NR1H2NR1H3ALDH1A1GLATSHR | |
| SCHEMBL10482427 | 0.80 | PTPN1 (0.36) | NR1H2NR1H3POLQ | |
| SCHEMBL9676347 | 0.77 | ALDH1A1 (0.52) | NR1H2NR1H3ALDH1A1GLATSHR | |
| SCHEMBL3343176 | 0.75 | ALDH1A1 (0.50) | NR1H2NR1H3ALDH1A1GLATSHR | |
| SCHEMBL3343171 | 0.75 | ALDH1A1 (0.50) | NR1H2NR1H3ALDH1A1GLATSHR | |
| SCHEMBL15015552 | 0.75 | ALDH1A1 (0.50) | NR1H2NR1H3ALDH1A1GLATSHR | |
| Hydrochloric Acid SCHEMBL8940097 | 0.74 | ALDH1A1 (0.48) | NR1H2NR1H3ALDH1A1GLATSHR | |
| SCHEMBL9324872 | 0.74 | TSHR (0.48) | NR1H2NR1H3ALDH1A1GLATSHR | |
| SCHEMBL8768924 | 0.72 | NR1H2 (0.50) | NR1H2NR1H3TP53MAPT | |
| SCHEMBL30401308 | 0.72 | TSHR (0.47) | NR1H2NR1H3ALDH1A1GLATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509495-A1 | ANILINO LIVER X-RECEPTOR MODULATORS | Pharmacia Corporation (US) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003099769-A1 | ANILINO LIVER X-RECEPTOR MODULATORS | PHARMACIA CORPORATION (US) | 2003-12-04 | — | — | WO | disclosed |