Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 11/20 | 0.57 |
| ▸ | HNF4A | P41235 | 7/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.47 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.44 |
| ▸ | RARA | P10276 | 3/20 | 0.41 |
| ▸ | RARB | P10826 | 3/20 | 0.41 |
| ▸ | RARG | P13631 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239678 | 0.88 | RXRA (0.71) | RXRAHNF4ACYP3A4CYP26A1CYP26B1 | |
| SCHEMBL6240838 | 0.83 | RXRA (0.51) | RXRAHNF4ACYP3A4CYP26A1CYP26B1 | |
| SCHEMBL6238471 | 0.83 | RXRA (0.57) | RXRAHNF4ACYP3A4CYP26A1CYP26B1 | |
| SCHEMBL6238178 | 0.78 | RXRA (0.56) | RXRAHNF4ACYP3A4CYP26A1 | |
| SCHEMBL6242229 | 0.76 | RXRA (0.43) | RXRAHNF4ACYP3A4CYP26A1CYP26B1 | |
| SCHEMBL28823599 | 0.75 | MAPT (0.60) | CA12CA1CA2CA9CA14 | |
| SCHEMBL6269934 | 0.74 | RXRA (0.59) | RXRAHNF4ACYP3A4CYP26A1RARA | |
| SCHEMBL8016426 | 0.74 | RXRA (0.53) | RXRAHNF4ACYP3A4CYP26A1CYP26B1 | |
| SCHEMBL9524356 | 0.74 | CYP3A4 (0.68) | RXRACYP3A4CYP26A1CYP26B1RARA | |
| SCHEMBL6237941 | 0.73 | RXRA (1.00) | RXRAHNF4ACYP3A4CYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | disclosed |