Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 15/20 | 0.71 |
| ▸ | HNF4A | P41235 | 8/20 | 0.71 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.57 |
| ▸ | RXRB | P28702 | 1/20 | 0.52 |
| ▸ | RARA | P10276 | 3/20 | 0.51 |
| ▸ | RARB | P10826 | 3/20 | 0.51 |
| ▸ | RARG | P13631 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6237205 | 0.88 | RXRA (0.57) | RXRAHNF4ACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL6237941 | 0.83 | RXRA (1.00) | RXRAHNF4ACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL6239086 | 0.82 | RXRA (0.78) | RXRAHNF4ACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL2685029 | 0.81 | RXRA (0.76) | RXRAHNF4ACYP26A1CYP26B1RXRB | |
| SCHEMBL6914152 | 0.80 | RXRA (1.00) | RXRAHNF4ARXRBRARARARB | |
| SCHEMBL6240261 | 0.79 | RXRA (0.73) | RXRAHNF4ACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL6238163 | 0.78 | RXRA (0.72) | RXRAHNF4ACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL6915718 | 0.78 | RXRA (0.77) | RXRAHNF4ACYP26A1CYP26B1RXRB | |
| SCHEMBL6240778 | 0.77 | RXRA (0.72) | RXRAHNF4ACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL6239260 | 0.77 | RXRA (0.78) | RXRAHNF4ACYP26A1CYP3A4CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | disclosed |