Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MARS1 | P56192 | 1/20 | 0.47 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192476 | 0.87 | KMT2A (0.58) | ALDH1A1SMN1; SMN2KMT2AUSP2HSD17B10 | |
| SCHEMBL6370547 | 0.83 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2KMT2AUSP2HSD17B10 | |
| SCHEMBL6371050 | 0.82 | KMT2A (0.67) | ALDH1A1SMN1; SMN2KMT2AUSP2HSD17B10 | |
| SCHEMBL6378549 | 0.82 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2KMT2AUSP2HSD17B10 | |
| SCHEMBL6371967 | 0.80 | SMN1; SMN2 (0.63) | ALDH1A1SMN1; SMN2KMT2AHSD17B10TSHR | |
| SCHEMBL6133942 | 0.79 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2KMT2AUSP2HSD17B10 | |
| SCHEMBL21384024 | 0.79 | MARS1 (0.43) | ALDH1A1SMN1; SMN2KMT2AUSP2HSD17B10 | |
| SCHEMBL6376456 | 0.78 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2KMT2AKDM4EMAPT | |
| SCHEMBL104990 | 0.77 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KMT2AKDM4EMAPT | |
| SCHEMBL2455065 | 0.77 | GRN (0.64) | SMN1; SMN2KMT2AHPGDPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050256122-A1 | Substituted pyridazinones | PHARMACIA CORPORATION | 2005-11-17 | — | — | US | disclosed |
| WO-2005007632-A1 | SUBSTITUTED PYRIDAZINONES AS INHIBITORS OF P38 | PHARMACIA CORPORATION (US) | 2005-01-27 | — | — | WO | disclosed |
| US-20050020594-A1 | Substituted pyridazinones | PHARMACIA CORPORATION | 2005-01-27 | — | — | US | disclosed |
| US-20040142932-A1 | Substituted pyridazinones | PHARMACIA CORPORATION | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142932-A1 | Substituted pyridazinones | MAP4K2, MAPK6, MAP3K6 | ALDH1A1 1889/4885SMN1; SMN2 1185/4885KMT2A 4458/4885 |
| US-20050020594-A1 | Substituted pyridazinones | MAP4K2, MAPK6, MAP3K6 | ALDH1A1 2217/4885SMN1; SMN2 1153/4885KMT2A 4449/4885 |
| US-20050256122-A1 | Substituted pyridazinones | MAP4K2, MAPK6, MAP3K6 | ALDH1A1 2217/4885SMN1; SMN2 1153/4885KMT2A 4449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.