Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | RPS6KB2 | Q9UBS0 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1259501 | 0.80 | CYP1A2 (0.55) | CYP1A2MAPTKMT2AMEN1HTT | |
| SCHEMBL31399941 | 0.80 | CYP1A2 (0.55) | CYP1A2MAPTKMT2AMEN1HTT | |
| SCHEMBL6237533 | 0.79 | RHOA (0.48) | CYP1A2RPS6KB2MAPTKMT2AMEN1 | |
| SCHEMBL1128864 | 0.78 | RPS6KB2 (0.58) | RPS6KB2ALDH1A1SMN1; SMN2LMNATDP1 | |
| SCHEMBL7696744 | 0.77 | RPS6KB2 (0.77) | RPS6KB2ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL6235717 | 0.76 | RPS6KB2 (0.66) | RPS6KB2MAPTKMT2AMEN1HTT | |
| SCHEMBL6261454 | 0.76 | NPC1 (0.62) | CYP1A2MAPTKMT2AMEN1HTT | |
| SCHEMBL1903020 | 0.76 | LMNA (0.62) | CYP1A2RPS6KB2MAPTKMT2AMEN1 | |
| SCHEMBL6239581 | 0.76 | ABCG2 (0.54) | CYP1A2MAPTKMT2AMEN1HTT | |
| SCHEMBL577663 | 0.75 | MAPT (0.44) | CYP1A2RPS6KB2MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |