SCHEMBL623739

SCHEMBL623739

CCOC(=O)c1sc(SC)c(C#N)c1N

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.53
KDM4E B2RXH2 1/20 0.48
ALDH1A1 P00352 1/20 0.48
HPGD P15428 1/20 0.48
LMNA P02545 1/20 0.48
FNTA P49354 12/20 0.47
FNTB P49356 12/20 0.47
RXFP1 Q9HBX9 1/20 0.46
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
APOBEC3G Q9HC16 1/20 0.44
ADORA2A P29274 1/20 0.44
ADORA3 P0DMS8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9865456 0.88 L3MBTL1 (0.55) L3MBTL1KDM4EALDH1A1HPGDFNTA
SCHEMBL3401657 0.85 GRIA4 (0.45) L3MBTL1KDM4EALDH1A1HPGDRXFP1
SCHEMBL622911 0.84 KDM4E (0.49) L3MBTL1KDM4EALDH1A1HPGDFNTA
SCHEMBL623479 0.82 L3MBTL1 (0.70) L3MBTL1KDM4EALDH1A1HPGDRXFP1
SCHEMBL3135234 0.82 L3MBTL1 (0.58) L3MBTL1KDM4EALDH1A1HPGDRXFP1
SCHEMBL8281789 0.82 LMNA (0.55) L3MBTL1KDM4EALDH1A1HPGDLMNA
SCHEMBL3139129 0.81 FNTA (0.63) L3MBTL1KDM4EALDH1A1HPGDLMNA
Hydrochloric Acid SCHEMBL1008231 0.81 LMNA (0.54) L3MBTL1KDM4EALDH1A1HPGDLMNA
SCHEMBL3128683 0.80 L3MBTL1 (0.56) L3MBTL1KDM4EALDH1A1HPGDRXFP1
SCHEMBL6644214 0.79 GRIA4 (0.47) L3MBTL1KDM4EALDH1A1HPGDLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116218033-A Application of organic material in preparing color-changeable polymer material 四川大学 2023-06-06 CN claimed
CN-116218033-B Application of organic material in preparing color-changeable polymer material 四川大学 2025-03-14 CN disclosed
CN-116218033-A Application of organic material in preparing color-changeable polymer material 四川大学 2023-06-06 CN disclosed
CN-110759900-B Preparation method and application of thiophene compound 沈阳药科大学 2021-07-30 CN disclosed
CN-110759900-A Preparation method and application of thiophene compound 沈阳药科大学 2020-02-07 CN disclosed
US-9139589-B2 Heteroaryls and uses thereof MILLENNIUM PHARMACEUTICALS, INC. (US) 2015-09-22 US disclosed
US-9139589-B2 Heteroaryls and uses thereof MILLENNIUM PHARMACEUTICALS, INC. (US) 2015-09-22 US disclosed
US-20150175563-A1 HETEROARYLS AND USES THEREOF MILLENNIUM PHARM INC (US) 2015-06-25 US disclosed
US-20150175593-A1 HETEROARYLS AND USES THEREOF MILLENNIUM PHARM INC (US) 2015-06-25 US disclosed
US-20150175593-A1 HETEROARYLS AND USES THEREOF MILLENNIUM PHARM INC (US) 2015-06-25 US disclosed
EP-1706395-A1 THIOPHENE AND FURAN COMPOUNDS ELI LILLY AND COMPANY (US) 2006-10-04 EP disclosed
WO-2006003096-A1 CONDENSED THIOPHENE DERIVATIVES AND THEIR USE AS CYCLIC GLP-1 AGONISTS NOVO NORDISK A/S (DK) 2006-01-12 WO disclosed
WO-2005070916-A1 THIOPHENE AND FURAN COMPOUNDS ELI LILLY AND COMPANY (US) 2005-08-04 WO disclosed
EP-0609371-B1 THIENOPYRAZINE-2,3-DIONES USEFUL FOR TREATING CNS DISORDERS, AND THEIR PREPARATION. NOVO NORDISK AS (DK) 1996-04-24 EP disclosed
EP-0609371-A1 THIENOPYRAZINE-2,3-DIONES AND THEIR PREPARATION AND USE. NOVO NORDISK AS (DK) 1994-08-10 EP disclosed
US-5284847-A Neurological and psychological disorders; antagonist at the glycine binding site on the N-methyl-D-aspartate receptor complex NOVO NORDISK A/S (DK) 1994-02-08 US disclosed
WO-1993008197-A1 THIENOPYRAZINE-2,3-DIONES AND THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1993-04-29 WO disclosed
US-4994485-A Seed and soil fungi, bacteria DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1991-02-19 US disclosed
EP-0234622-B1 NEW THIO COMPOUNDS HAVING FUNGICIDAL ACTIVITY DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1990-06-27 EP disclosed
EP-0234622-A1 New thio compounds having fungicidal activity DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1987-09-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150175563-A1 HETEROARYLS AND USES THEREOF PIK3R1, PIK3R2, PIK3R3 L3MBTL1 466/4885KDM4E 4086/4885ALDH1A1 429/4885
US-20150175593-A1 HETEROARYLS AND USES THEREOF PIK3R1, PIK3R2, PIK3R3 L3MBTL1 651/4885KDM4E 3971/4885ALDH1A1 395/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.