Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 1.00 |
| ▸ | GSK3A | P49840 | 8/20 | 1.00 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.78 |
| ▸ | IGF1R | P08069 | 3/20 | 0.76 |
| ▸ | INSR | P06213 | 2/20 | 0.76 |
| ▸ | CDK2 | P24941 | 5/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL623771 | 1.00 | GSK3B (1.00) | GSK3BGSK3APIK3CGIGF1RINSR | |
| SCHEMBL4206814 | 0.88 | PIK3CG (1.00) | GSK3BGSK3APIK3CGIGF1RINSR | |
| SCHEMBL4206811 | 0.88 | PIK3CG (1.00) | GSK3BGSK3APIK3CGIGF1RINSR | |
| SCHEMBL623774 | 0.86 | IGF1R (1.00) | GSK3BGSK3APIK3CGIGF1RINSR | |
| SCHEMBL623776 | 0.86 | IGF1R (1.00) | GSK3BGSK3APIK3CGIGF1RINSR | |
| SCHEMBL623775 | 0.86 | IGF1R (1.00) | GSK3BGSK3APIK3CGIGF1RINSR | |
| SCHEMBL623633 | 0.85 | PIK3CG (0.78) | GSK3BGSK3APIK3CGIGF1RINSR | |
| SCHEMBL623632 | 0.85 | PIK3CG (0.78) | GSK3BGSK3APIK3CGIGF1RINSR | |
| SCHEMBL622538 | 0.82 | PIK3CG (0.79) | GSK3BGSK3APIK3CGIGF1RINSR | |
| SCHEMBL622537 | 0.82 | PIK3CG (0.79) | GSK3BGSK3APIK3CGIGF1RINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9255088-B2 | Premature-termination-codons readthrough compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-02-09 | — | — | US | disclosed |
| US-20130274283-A1 | PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-10-17 | — | — | US | disclosed |
| WO-2012021707-A2 | PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274283-A1 | PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS | UPF1, NUDT21, RNGTT | GSK3B 4721/4885GSK3A 4773/4885PIK3CG 3728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.