Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | GPR88 | Q9GZN0 | 8/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28246517 | 0.90 | ELANE (0.43) | ELANEPOLBPPARGPPARA | |
| SCHEMBL28212655 | 0.89 | ALDH1A1 (0.45) | ELANEALDH1A1 | |
| SCHEMBL8162316 | 0.88 | ELANE (0.42) | ELANEALDH1A1LMNACYP19A1FFAR1 | |
| SCHEMBL28547262 | 0.88 | ALDH1A1 (0.47) | ALDH1A1PPARGPPARA | |
| SCHEMBL27683318 | 0.87 | TRPA1 (0.45) | ELANEPOLBALDH1A1LMNACYP19A1 | |
| SCHEMBL27765405 | 0.87 | TRPA1 (0.45) | ELANEPOLBALDH1A1LMNACYP19A1 | |
| SCHEMBL27581241 | 0.86 | ELANE (0.59) | ELANEPOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL27581304 | 0.85 | ELANE (0.41) | ELANEALDH1A1LMNACYP19A1FFAR1 | |
| SCHEMBL27498005 | 0.84 | KMT2A (0.49) | ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL27899878 | 0.83 | ELANE (0.45) | ELANEPOLBALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005010202-A2 | PHENYL ACETIC ACID DERIVATIVES AS HEPATOCYTE NUCLEAR FACTOR 4α (HNF-4α) MODULATOR COMPOUNDS | LIGAND PHARMACUETICALS INCORPORATED (US) | 2005-02-03 | — | — | WO | claimed |
| WO-2005010202-A2 | PHENYL ACETIC ACID DERIVATIVES AS HEPATOCYTE NUCLEAR FACTOR 4α (HNF-4α) MODULATOR COMPOUNDS | LIGAND PHARMACUETICALS INCORPORATED (US) | 2005-02-03 | — | — | WO | disclosed |