SCHEMBL6238

SCHEMBL6238

O=C(O)c1ccc([N+](=O)[O-])c(F)c1

nearest known ligand 0.70

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CASP6 P55212 1/20 0.70
TSHR P16473 2/20 0.64
LMNA P02545 1/20 0.59
TDP1 Q9NUW8 2/20 0.58
ATM Q13315 1/20 0.58
HCAR3 P49019 8/20 0.54
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
APEX1 P27695 1/20 0.50
TP53 P04637 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30001328 1.00 CASP6 (0.70) CASP6TSHRLMNATDP1ATM
Hydrochloric Acid SCHEMBL5568198 0.98 CASP6 (0.68) CASP6TSHRLMNATDP1ATM
SCHEMBL24994 0.85 CASP6 (0.70) CASP6TSHRLMNAHCAR3MEN1
SCHEMBL6648516 0.84 HCAR3 (0.54) CASP6TSHRLMNAHCAR3
SCHEMBL30149157 0.84 ATM (0.56) CASP6TSHRLMNATDP1ATM
SCHEMBL275422 0.84 ATM (0.56) CASP6TSHRLMNATDP1ATM
SCHEMBL31176043 0.84 PARP1 (0.60) CASP6TSHRLMNATDP1ATM
SCHEMBL11248434 0.84 ATM (0.56) CASP6TSHRTDP1ATMMEN1
SCHEMBL1937077 0.84 PARP1 (0.60) CASP6TSHRLMNATDP1ATM
SCHEMBL10903666 0.83 MAPK1 (0.68) CASP6TSHRLMNATDP1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 936 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4127157-B1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS ENCODIA INC (US) 2026-02-11 EP claimed
CN-118812209-A Preparation method of polyvinyl alcohol emulsion modified cement paste generated in situ 海南大学 2024-10-22 CN claimed
CN-118621569-A Polyvinyl alcohol fiber surface acetalation modification method 海南大学 2024-09-10 CN claimed
CN-117945917-A Preparation method of 3-fluoro-4-nitrobenzoic acid 衢州康鹏化学有限公司 2024-04-30 CN claimed
CN-117447327-A Preparation method of 3-fluoro-4-nitrobenzoic acid 上海万溯药业有限公司 2024-01-26 CN claimed
US-20240011009-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2024-01-11 US claimed
CN-112266328-B Synthetic route and preparation method of 3-fluoro-4-nitrobenzaldehyde 郑州萃智医药科技有限公司 2023-11-03 CN claimed
US-20230220589-A1 POLYPEPTIDE TERMINAL BINDERS AND USES THEREOF Encodia, Inc. (US) 2023-07-13 US claimed
CN-112851646-B Preparation method of tergolian prazan 中国医学科学院药物研究所 2023-06-13 CN claimed
EP-4127157-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2023-02-08 EP claimed
WO-2022267470-A1 SEH INHIBITOR OR PHARMACEUTICALLY ACCEPTABLE COMPOSITION THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF 沈阳药科大学 2022-12-29 WO claimed
WO-2022072560-A1 POLYPEPTIDE TERMINAL BINDERS AND USES THEREOF Encodia, Inc. (US) 2022-04-07 WO claimed
WO-2021194908-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2021-09-30 WO claimed
CN-112851646-A Preparation method of Tegolrazan 中国医学科学院药物研究所 2021-05-28 CN claimed
CN-112266328-A Synthetic route and preparation method of 3-fluoro-4-nitrobenzaldehyde 郑州萃智医药科技有限公司 2021-01-26 CN claimed
US-20260132147-A1 BAX INHIBITORS AND USES THEREOF CASE WESTERN RESERVE UNIV (US) 2026-05-14 US disclosed
US-12595249-B2 Aryl ether-substituted heterocyclic compounds as glpir agonists MINDRANK AI LTD. (CN) 2026-04-07 US disclosed
US-4629811-A 3-sulfonylamino-4-aminobenzophenone derivatives ELI LILLY AND COMPANY (US) 1986-12-16 US disclosed
US-4483986-A 4-Nitrobenzophenone compounds ELI LILLY AND COMPANY (US) 1984-11-20 US disclosed
EP-0093590-A1 Process for the preparation of sulfonylamino benzophenones ELI LILLY AND COMPANY (US) 1983-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260132147-A1 BAX INHIBITORS AND USES THEREOF BAX, BCL2, BAK1 CASP6 22/4885TSHR 3456/4885LMNA 76/4885
US-12595249-B2 Aryl ether-substituted heterocyclic compounds as glpir agonists GLP1R, GIPR, GCGR CASP6 1135/4885TSHR 32/4885LMNA 1936/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.