Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.50 |
| ▸ | PTGFR | P43088 | 1/20 | 0.50 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.50 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.50 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.50 |
| ▸ | PTGES | O14684 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Naphthylacetic Acid SCHEMBL238445 | 0.89 | NR1H4 (0.71) | NR1H4CYP1A2AKR1B1PTGS1ABCC4 | |
| 2-Naphthylacetic Acid SCHEMBL30493868 | 0.89 | NR1H4 (0.71) | NR1H4CYP1A2AKR1B1PTGS1ABCC4 | |
| 2-Naphthylacetic Acid SCHEMBL28641469 | 0.89 | NR1H4 (0.71) | NR1H4CYP1A2AKR1B1PTGS1ABCC4 | |
| 2-Naphthylacetic Acid SCHEMBL29366514 | 0.89 | NR1H4 (0.71) | NR1H4CYP1A2AKR1B1PTGS1ABCC4 | |
| 2-Naphthylacetic Acid SCHEMBL10453180 | 0.87 | NR1H4 (0.69) | NR1H4CYP1A2AKR1B1PTGS1ABCC4 | |
| 2-Naphthylacetic Acid SCHEMBL11045683 | 0.87 | NR1H4 (0.69) | NR1H4CYP1A2AKR1B1PTGS1ABCC4 | |
| 2-Naphthylacetic Acid SCHEMBL11437704 | 0.87 | NR1H4 (0.69) | NR1H4CYP1A2AKR1B1PTGS1ABCC4 | |
| 2-Naphthylacetic Acid SCHEMBL7861322 | 0.85 | NR1H4 (0.67) | NR1H4CYP1A2AKR1B1PTGS1ABCC4 | |
| 2-Naphthylacetic Acid SCHEMBL29180271 | 0.85 | NR1H4 (0.67) | NR1H4CYP1A2AKR1B1PTGS1ABCC4 | |
| 2-Naphthylacetic Acid SCHEMBL11102091 | 0.85 | NR1H4 (0.67) | NR1H4CYP1A2AKR1B1PTGS1ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005010202-A2 | PHENYL ACETIC ACID DERIVATIVES AS HEPATOCYTE NUCLEAR FACTOR 4α (HNF-4α) MODULATOR COMPOUNDS | LIGAND PHARMACUETICALS INCORPORATED (US) | 2005-02-03 | — | — | WO | claimed |
| WO-2005010202-A2 | PHENYL ACETIC ACID DERIVATIVES AS HEPATOCYTE NUCLEAR FACTOR 4α (HNF-4α) MODULATOR COMPOUNDS | LIGAND PHARMACUETICALS INCORPORATED (US) | 2005-02-03 | — | — | WO | disclosed |