Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 4/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | BID | P55957 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6238590 | 0.85 | MMP1 (0.46) | MMP1ADAM17S1PR1S1PR5MMP13 | |
| SCHEMBL6240112 | 0.83 | MMP1 (0.50) | MMP1ADAM17S1PR1S1PR5MMP13 | |
| SCHEMBL7133979 | 0.79 | ADAM17 (0.54) | MMP1ADAM17MMP13MMP9MMP3 | |
| SCHEMBL7132748 | 0.79 | ADAM17 (0.54) | MMP1ADAM17MMP13MMP9MMP3 | |
| SCHEMBL6236695 | 0.79 | ADAM17 (0.54) | MMP1ADAM17MMP13MMP9MMP3 | |
| SCHEMBL7132752 | 0.79 | ADAM17 (0.54) | MMP1ADAM17MMP13MMP9MMP3 | |
| SCHEMBL6237169 | 0.76 | ADAM17 (0.58) | MMP1ADAM17MMP13MMP9MMP3 | |
| SCHEMBL6233609 | 0.76 | ADAM17 (0.58) | MMP1ADAM17MMP13MMP9MMP3 | |
| SCHEMBL6239293 | 0.75 | MMP1 (0.53) | MMP1ADAM17MMP13MMP9MMP3 | |
| SCHEMBL6240908 | 0.75 | MMP1 (0.49) | MMP1ADAM17S1PR1S1PR5MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104412-B1 | TACE INHIBITORS | PFIZER PROD INC (US) | 2005-06-15 | — | — | EP | disclosed |