Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 10/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 3/20 | 0.43 |
| ▸ | PLAT | P00750 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2251446 | 0.94 | DYRK1A (0.49) | DYRK1ADYRK2CCNA2CDK2CDK5 | |
| SCHEMBL625503 | 0.86 | PIM1 (0.52) | DYRK1APIM1KCNH2FYN | |
| SCHEMBL1947244 | 0.81 | FYN (0.57) | PIM1FYN | |
| SCHEMBL2257597 | 0.80 | DYRK1A (0.44) | DYRK1ADYRK2CCNA2CDK2CDK5 | |
| SCHEMBL625653 | 0.80 | PIK3CA (0.54) | — | |
| SCHEMBL1945252 | 0.80 | DYRK1A (0.52) | DYRK1APIM1KCNH2PIM3PIM2 | |
| SCHEMBL27815636 | 0.78 | DYRK3 (0.46) | DYRK1ADYRK2CCNA2CDK2CDK5 | |
| SCHEMBL15603239 | 0.78 | DYRK1A (0.46) | DYRK1ADYRK2CCNA2CDK2CDK5 | |
| SCHEMBL1944248 | 0.78 | FYN (0.43) | FYN | |
| SCHEMBL623881 | 0.77 | FYN (0.60) | PIM1KCNH2PIM3PIM2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |