Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685713 | 0.86 | KMT2A (0.62) | KMT2ALMNAOPRM1OPRL1OGFRL1 | |
| SCHEMBL9480993 | 0.85 | LMNA (0.52) | KMT2ALMNAOPRM1OPRL1OGFRL1 | |
| SCHEMBL11318061 | 0.85 | LMNA (0.49) | KMT2ALMNAOPRM1OPRL1OGFRL1 | |
| SCHEMBL2706382 | 0.84 | MAPKAPK2 (0.44) | OPRM1OGFRL1 | |
| SCHEMBL10617106 | 0.83 | KMT2A (0.51) | KMT2ALMNAOPRM1OPRL1OGFRL1 | |
| SCHEMBL2705403 | 0.83 | CFTR (0.42) | LMNAOPRM1OGFRL1MAPTALDH1A1 | |
| SCHEMBL2780429 | 0.83 | MAPKAPK2 (0.45) | KMT2ALMNAMEN1MAPT | |
| SCHEMBL2706845 | 0.83 | MAPKAPK2 (0.52) | LMNATRPA1TRPV1KDM4EMAPT | |
| SCHEMBL11458021 | 0.83 | KMT2A (0.54) | KMT2ALMNATRPA1TRPV1MEN1 | |
| SCHEMBL9685278 | 0.83 | KMT2A (0.40) | KMT2AOPRM1OGFRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891187-B1 | USE OF DERIVATIVES OF TETRAHYDRO-BETA-CARBOLINES AS ANTIMETASTATIC AGENTS | HOFFMANN LA ROCHE (CH) | 2002-01-30 | — | — | EP | claimed |
| US-6069150-A | METALLOPROTRINASE INHIBITOR | F. HOFFMAN-LA ROCHE AG (CH) | 2000-05-30 | — | — | US | claimed |
| EP-0273321-B1 | 7-BROMO-BETA-CARBOLINE COMPOUND AND METHOD FOR PRODUCING SAME | Kawaken Fine Chemicals Co., Ltd. (JP) | 1992-04-22 | — | — | EP | claimed |
| US-4894457-A | BROMINATION, HYDROLYSIS | KAWAKEN FINE CHEMICALS CO., LTD. (JP) | 1990-01-16 | — | — | US | claimed |
| EP-0273321-A1 | 7-Bromo-beta-carboline compound and method for producing same | Kawaken Fine Chemicals Co., Ltd. (JP) | 1988-07-06 | — | — | EP | claimed |
| US-20250324119-A1 | SYSTEMS AND METHODS FOR ADAPTIVE ADJUSTMENT OF ADVERTISEMENT BOUNDARIES IN MEDIA | NIELSEN CO US LLC (US) | 2025-10-16 | — | — | US | disclosed |
| US-12363363-B2 | Systems and methods for adaptive adjustment of advertisement boundaries in media | THE NIELSEN COMPANY (US), LLC (US) | 2025-07-15 | — | — | US | disclosed |
| US-20240040173-A1 | SYSTEMS AND METHODS FOR ADAPTIVE ADJUSTMENT OF ADVERTISEMENT BOUNDARIES IN MEDIA | THE NIELSEN COMPANY (US), LLC (US) | 2024-02-01 | — | — | US | disclosed |
| US-20050137220-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | PHARMACIA CORPORATION (US) | 2005-06-23 | — | — | US | disclosed |
| WO-2005009370-A2 | BETA-CARBOLINE COMPOUNDS AND ANALOGUES THEREOF AND THEIR USE AS MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITORS | PHARMACIA CORPORATION (US) | 2005-02-03 | — | — | WO | disclosed |
| EP-0891187-B1 | USE OF DERIVATIVES OF TETRAHYDRO-BETA-CARBOLINES AS ANTIMETASTATIC AGENTS | HOFFMANN LA ROCHE (CH) | 2002-01-30 | — | — | EP | disclosed |
| US-6069150-A | METALLOPROTRINASE INHIBITOR | F. HOFFMAN-LA ROCHE AG (CH) | 2000-05-30 | — | — | US | disclosed |
| EP-0273321-B1 | 7-BROMO-BETA-CARBOLINE COMPOUND AND METHOD FOR PRODUCING SAME | Kawaken Fine Chemicals Co., Ltd. (JP) | 1992-04-22 | — | — | EP | disclosed |
| US-4894457-A | BROMINATION, HYDROLYSIS | KAWAKEN FINE CHEMICALS CO., LTD. (JP) | 1990-01-16 | — | — | US | disclosed |
| EP-0273321-A1 | 7-Bromo-beta-carboline compound and method for producing same | Kawaken Fine Chemicals Co., Ltd. (JP) | 1988-07-06 | — | — | EP | disclosed |
| US-4336256-A | TREATMENT OF ANOXIA, DEPRESSION AND IN PSYCHOTROPIC THERAPY | SYNTHELABO (FR) | 1982-06-22 | — | — | US | disclosed |
| US-4272539-A | ANOXIA, ANTIDEPRESSANTS | SYNTHELABO (FR) | 1981-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137220-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | MAPKAPK2, MAP4K2, MAP3K2 | KMT2A 500/4885LMNA 3942/4885OPRM1 2196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.