Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 8/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235512 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2PDE5ADRD2CYP2D6DRD4 | |
| SCHEMBL6016946 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2PDE5ADRD2CYP2D6DRD4 | |
| SCHEMBL4841035 | 0.77 | PDE5A (0.46) | PDE5ADRD2CYP2D6DRD4DRD3 | |
| SCHEMBL6231918 | 0.75 | DRD2 (0.39) | DRD2CYP2D6DRD4DRD3ADRA2A | |
| SCHEMBL6856196 | 0.75 | KDM4E (0.38) | SMN1; SMN2DRD2TSHRALDH1A1 | |
| SCHEMBL4829473 | 0.75 | DRD2 (0.46) | PDE5ADRD2CYP2D6DRD4DRD3 | |
| SCHEMBL6229931 | 0.75 | GALR1 (0.42) | SMN1; SMN2CYP2D6CYP2C19MEN1KMT2A | |
| SCHEMBL14268377 | 0.74 | DRD2 (0.42) | DRD2CYP2D6DRD4DRD3ADRA2A | |
| SCHEMBL5553491 | 0.73 | GALR1 (0.46) | DRD2 | |
| SCHEMBL5553557 | 0.72 | SMN1; SMN2 (0.37) | SMN1; SMN2CYP2D6ADRA2ACYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560817-A1 | METHODS AND COMPOSITIONS OF NOVEL TRIAZINE COMPOUNDS | Reddy US Therapeutics, Inc. (US) | 2005-08-10 | — | — | EP | claimed |
| WO-2004026844-A1 | METHODS AND COMPOSITIONS OF NOVEL TRIAZINE COMPOUNDS | REDDY US THERAPEUTICS, INC. (US) | 2004-04-01 | — | — | WO | claimed |