Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4857407 | 0.90 | KMT2A (0.45) | MAPTRAB9AGAAALDH1A1KMT2A | |
| SCHEMBL4852458 | 0.81 | KMT2A (0.54) | MAPTRAB9AGAAALDH1A1KMT2A | |
| SCHEMBL1067199 | 0.79 | SIRT2 (0.54) | SIRT2ALDH1A1LMNACYP19A1 | |
| Hydrochloric Acid SCHEMBL1788098 | 0.78 | SIRT2 (0.53) | SIRT2ALDH1A1LMNACYP19A1 | |
| SCHEMBL6437317 | 0.75 | NPSR1 (0.52) | MAPTALDH1A1KMT2ALMNAPKM | |
| SCHEMBL4850663 | 0.75 | LMNA (0.47) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL28985286 | 0.74 | PKM (0.49) | MAPTRAB9AGAAALDH1A1KMT2A | |
| SCHEMBL28775731 | 0.73 | NPSR1 (0.50) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL2777885 | 0.73 | KMT2A (0.54) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL10936594 | 0.73 | MEN1 (0.63) | MAPTRAB9AALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606268-A1 | HETEROCYCLIC KINASE INHIBITORS | Abbott Laboratories (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004076424-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-09-10 | — | — | WO | disclosed |