SCHEMBL6239081

SCHEMBL6239081

CC(C)(C)OC(=O)NCCC(=O)c1cccc(F)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 1/20 0.44
CTSK P43235 1/20 0.44
NQO2 P16083 1/20 0.44
CTNNB1 P35222 3/20 0.43
WNT3A P56704 3/20 0.43
KDM4E B2RXH2 4/20 0.43
MAPT P10636 4/20 0.43
HPGD P15428 4/20 0.43
HTT P42858 4/20 0.43
NPC1 O15118 4/20 0.43
MEN1 O00255 2/20 0.43
LMNA P02545 2/20 0.43
TSHR P16473 2/20 0.43
KMT2A Q03164 2/20 0.43
ALOX12 P18054 1/20 0.43
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
NPSR1 Q6W5P4 2/20 0.42
RAB9A P51151 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2241024 0.92 CA1 (0.48) CTSSCTSKNQO2CTNNB1WNT3A
SCHEMBL4367628 0.86 TDP1 (0.43) NQO2KDM4EMAPTHPGDNPC1
SCHEMBL16079979 0.85 CTNNB1 (0.49) NQO2CTNNB1WNT3AKDM4EMAPT
SCHEMBL2166736 0.85 NQO2 (0.56) NQO2CTNNB1KDM4EMAPTHPGD
SCHEMBL16079978 0.84 TP53BP1 (0.48) NQO2KDM4EMAPTHPGDNPC1
SCHEMBL13323959 0.84 L3MBTL1 (0.49) CTSSCTSKNQO2KDM4EMAPT
SCHEMBL942893 0.83 IDO1 (0.51) KDM4EMAPTHPGDMEN1LMNA
SCHEMBL24363850 0.83 ADRB2 (0.43) CTSSCTSKCTNNB1WNT3AKDM4E
SCHEMBL31145115 0.83 ADRB2 (0.43) CTSSCTSKCTNNB1WNT3AKDM4E
SCHEMBL18329401 0.81 KDM4E (0.42) CTSSCTSKKDM4EMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1539695-A1 N-4-PIPERIDINYL COMPOUNDS AS CCR5 MODULATORS AstraZeneca AB (SE) 2005-06-15 EP disclosed
EP-1490336-A1 PIPERIDINE OR 8-AZA-BICYCLO(3.2.1)OCT-3-YL DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY (ESPECIALLY CCR5) AstraZeneca AB (SE) 2004-12-29 EP disclosed
EP-1448525-A1 NOVEL PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS AstraZeneca AB (SE) 2004-08-25 EP disclosed
WO-2004018425-A1 N-4-PIPERIDINYL COMPOUNDS AS CCR5 MODULATORS ASTRAZENECA AB (SE) 2004-03-04 WO disclosed
WO-2003080574-A1 PIPERIDINE OR 8-AZA-BICYCLO[3.2.1]OCT-3-YL DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY (ESPECIALLY CCR5) ASTRAZENECA AB (SE) 2003-10-02 WO disclosed
WO-2003042178-A1 NOVEL PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS ASTRAZENECA AB (SE) 2003-05-22 WO disclosed