Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364796 | 0.85 | ADRA2A (0.45) | LPAR1TRPV4GAAHTTLMNA | |
| SCHEMBL1911429 | 0.84 | LPAR1 (0.50) | LPAR1TRPV4GAAHTTLMNA | |
| SCHEMBL27753971 | 0.80 | LPAR1 (0.48) | LPAR1TRPV4HTTLMNAALDH1A1 | |
| SCHEMBL18713894 | 0.80 | PLAU (0.43) | HTTLMNAALDH1A1MAPTKDM4E | |
| SCHEMBL1678998 | 0.79 | PTGS1 (0.49) | LPAR1TRPV4HTTALDH1A1MEN1 | |
| SCHEMBL30542148 | 0.78 | MAOB (0.55) | GAAMGAMSIMGAM2MAPT | |
| SCHEMBL9862160 | 0.78 | MAOB (0.55) | GAAMGAMSIMGAM2MAPT | |
| SCHEMBL11709428 | 0.78 | ADRA2A (0.54) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL13345090 | 0.78 | ACHE (0.54) | LPAR1GAAMGAMSIMGAM2 | |
| SCHEMBL31439778 | 0.78 | ADRA2A (0.54) | ALDH1A1MEN1KMT2AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606268-A1 | HETEROCYCLIC KINASE INHIBITORS | Abbott Laboratories (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004076424-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-09-10 | — | — | WO | disclosed |