Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 15/20 | 0.46 |
| ▸ | MMP1 | P03956 | 11/20 | 0.46 |
| ▸ | MMP3 | P08254 | 4/20 | 0.46 |
| ▸ | MMP9 | P14780 | 4/20 | 0.46 |
| ▸ | MMP13 | P45452 | 6/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6237324 | 0.90 | ADAM17 (0.55) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL7130071 | 0.90 | ADAM17 (0.55) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL7765006 | 0.85 | MMP1 (0.54) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL6237732 | 0.85 | MMP1 (0.54) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL6240560 | 0.85 | ADAM17 (0.49) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL6236919 | 0.85 | MMP1 (0.54) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL6241314 | 0.85 | MMP1 (0.54) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL7068813 | 0.85 | ADAM17 (0.49) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL7068818 | 0.85 | ADAM17 (0.49) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL6240863 | 0.85 | ADAM17 (0.54) | ADAM17MMP1MMP3MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104412-B1 | TACE INHIBITORS | PFIZER PROD INC (US) | 2005-06-15 | — | — | EP | disclosed |