Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10562342 | 0.82 | ALDH1A1 (0.50) | KDM4EMAPTCTSDHDAC7P2RX7 | |
| SCHEMBL31645320 | 0.81 | F2R (0.52) | KDM4EMAPTCTSDHDAC7P2RX7 | |
| SCHEMBL13407497 | 0.81 | SMN1; SMN2 (0.55) | KDM4EMAPTCTSDP2RX7ALDH1A1 | |
| SCHEMBL29627992 | 0.81 | SMN1; SMN2 (0.55) | KDM4EMAPTCTSDP2RX7ALDH1A1 | |
| SCHEMBL1637434 | 0.79 | CSNK2A1 (0.60) | KDM4EMAPTALDH1A1GFERGAA | |
| SCHEMBL20018152 | 0.78 | ALDH1A1 (0.68) | KDM4EMAPTCTSDP2RX7ALDH1A1 | |
| SCHEMBL1544112 | 0.78 | KAT6A (0.47) | KDM4EMAPTCTSDP2RX7ALDH1A1 | |
| SCHEMBL15047177 | 0.78 | LOXL2 (0.55) | KDM4EMAPTCTSDHDAC7P2RX7 | |
| SCHEMBL5504399 | 0.77 | SMN1; SMN2 (0.58) | KDM4EMAPTCTSDALDH1A1GFER | |
| Hydrochloric Acid SCHEMBL19547889 | 0.76 | SMN1; SMN2 (0.57) | KDM4EMAPTALDH1A1GFERMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320523-B1 | BRANCHED CHAIN AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | claimed |