Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 3/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079886 | 0.90 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL6079669 | 0.83 | HDAC3 (0.43) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL6078849 | 0.81 | BRAF (0.48) | NR1H4MEN1KMT2A | |
| SCHEMBL6240758 | 0.79 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL6207387 | 0.78 | KMT2A (0.47) | RAB9ANPC1SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL6238276 | 0.74 | EGFR (0.40) | — | |
| SCHEMBL6240453 | 0.72 | BLM (0.41) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL6257221 | 0.70 | ROCK2 (0.45) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL6079788 | 0.70 | MEN1 (0.52) | MEN1KMT2A | |
| SCHEMBL6237222 | 0.69 | MAPK14 (0.54) | MAPTMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005002673-A1 | RAF KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |