Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 4/20 | 0.53 |
| ▸ | RARG | P13631 | 7/20 | 0.39 |
| ▸ | RXRA | P19793 | 8/20 | 0.39 |
| ▸ | RARB | P10826 | 5/20 | 0.39 |
| ▸ | RARA | P10276 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 3/20 | 0.35 |
| ▸ | RXRG | P48443 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6242646 | 0.93 | HNF4A (0.56) | HNF4ARARGRXRARARBRARA | |
| SCHEMBL6240429 | 0.92 | HNF4A (0.52) | HNF4ARARGRXRARARBALDH1A1 | |
| SCHEMBL6242642 | 0.79 | HNF4A (0.68) | HNF4ARARGRXRARARBRARA | |
| SCHEMBL6242100 | 0.79 | HNF4A (0.49) | HNF4ARARGRXRARARBRARA | |
| SCHEMBL6240434 | 0.79 | HNF4A (0.59) | HNF4ARARGRXRARARBRARA | |
| SCHEMBL6242482 | 0.78 | HNF4A (0.44) | HNF4ARARGRXRARARBRARA | |
| SCHEMBL6242159 | 0.77 | HNF4A (0.48) | HNF4ARARGRXRARARBRARA | |
| SCHEMBL6239480 | 0.77 | RARG (0.49) | RARGRXRARARBRARAALDH1A1 | |
| SCHEMBL6240611 | 0.76 | RXRA (0.47) | HNF4ARARGRXRARARBRARA | |
| SCHEMBL6238072 | 0.76 | HNF4A (0.63) | HNF4ARARGRXRARARBRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | disclosed |