Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28681892 | 1.00 | CYP2C19 (0.40) | CYP2C19ALDH1A1TSHRUSP2LMNA | |
| Acetic Acid SCHEMBL30455783 | 0.88 | FFAR3 (0.41) | CYP2C19ALDH1A1TSHRUSP2LMNA | |
| Acetic Acid SCHEMBL30455781 | 0.88 | FFAR3 (0.41) | CYP2C19ALDH1A1TSHRUSP2LMNA | |
| Acetic Acid SCHEMBL27768285 | 0.88 | FFAR3 (0.41) | CYP2C19ALDH1A1TSHRUSP2LMNA | |
| SCHEMBL749447 | 0.86 | — | — | |
| SCHEMBL3168987 | 0.86 | ALDH1A1 (0.42) | CYP2C19ALDH1A1TSHR | |
| SCHEMBL5575197 | 0.86 | ALDH1A1 (0.42) | CYP2C19ALDH1A1TSHR | |
| SCHEMBL4955809 | 0.86 | ALDH1A1 (0.42) | CYP2C19ALDH1A1TSHR | |
| SCHEMBL27175 | 0.86 | — | — | |
| SCHEMBL21624980 | 0.86 | ALDH1A1 (0.42) | CYP2C19ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957903-A4 | PHARMACEUTICAL COMPOSITIONS AND METHODS | CODON PHARMACEUTICALS INC (US) | 2002-10-09 | — | — | EP | claimed |
| EP-0957903-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS | Codon Pharmaceuticals, Inc. (US) | 1999-11-24 | — | — | EP | claimed |
| WO-1998011882-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS | CODON PHARMACEUTICALS, INC. (US) | 1998-03-26 | — | — | WO | claimed |
| EP-1554326-A1 | EMULSIFIER-FREE MICROGEL | Bollig & Kemper GmbH & Co. KG (DE) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035646-A1 | EMULSIFIER-FREE MICROGEL | BOLLIG & KEMPER GMBH & CO. KG (DE) | 2004-04-29 | — | — | WO | disclosed |
| EP-0438090-B2 | Binder composition for the preparation of pigment pastes and aqueous coating compositions containing these pigment pastes | HERBERTS GESELLSCHAFTMIT BESCH (DE) | 2004-02-04 | — | — | EP | disclosed |
| EP-0957903-A4 | PHARMACEUTICAL COMPOSITIONS AND METHODS | CODON PHARMACEUTICALS INC (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-0654052-B2 | Process for preparing a polyol and polyisocyanate-based water-dilutable coating agent | DU PONT (US) | 2002-04-17 | — | — | EP | disclosed |
| EP-0850257-B1 | AQUEOUS BINDER DISPERSION USEFUL FOR PRODUCING HARDLY YELLOWING, HIGHLY GLOSSY COATINGS | BASF COATINGS AG (DE) | 2000-10-25 | — | — | EP | disclosed |
| EP-0928303-B1 | PROCESS FOR PREPARING AN AQUEOUS DISPERSION OF A POLYACRYLATE-MODIFIED POLYURETHANE-ALKYD RESIN AND THE USE OF SUCH A DISPERSION | BASF COATINGS AG (DE) | 2000-06-28 | — | — | EP | disclosed |
| EP-0957903-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS | Codon Pharmaceuticals, Inc. (US) | 1999-11-24 | — | — | EP | disclosed |
| EP-0654052-A1 | POLYOL AND POLYISOCYANATE-BASED WATER-DILUTABLE COATING AGENT, PROCESS FOR PREPARING THE SAME AND ITS USE | Herberts Gesellschaft mit beschränkter Haftung (DE) | 1995-05-24 | — | — | EP | disclosed |
| EP-0654051-A1 | WATER-DILUTABLE COATING BASED ON POLYOLS AND POLYISOCYANATES, PROCESS FOR PREPARING THE SAME AND ITS USE | Herberts Gesellschaft mit beschränkter Haftung (DE) | 1995-05-24 | — | — | EP | disclosed |
| EP-0654053-A1 | POLYOL AND POLYISOCYANATE-BASED WATER-DILUTABLE COATING, PROCESS FOR PREPARING THE SAME AND ITS USE | Herberts Gesellschaft mit beschränkter Haftung (DE) | 1995-05-24 | — | — | EP | disclosed |
| EP-0438090-B1 | Binder composition for the preparation of pigment pastes and aqueous coating compositions containing these pigment pastes | HERBERTS & CO GMBH (DE) | 1994-04-06 | — | — | EP | disclosed |
| WO-1994003513-A1 | POLYOL AND POLYISOCYANATE-BASED WATER-DILUTABLE COATING, PROCESS FOR PREPARING THE SAME AND ITS USE | Herberts Gesellschaft mit beschränkter Haftung (DE) | 1994-02-17 | — | — | WO | disclosed |
| WO-1994003512-A1 | POLYOL AND POLYISOCYANATE-BASED WATER-DILUTABLE COATING AGENT, PROCESS FOR PREPARING THE SAME AND ITS USE | Herberts Gesellschaft mit beschränkter Haftung (DE) | 1994-02-17 | — | — | WO | disclosed |
| WO-1994003511-A1 | WATER-DILUTABLE COATING BASED ON POLYOLS AND POLYISOCYANATES, PROCESS FOR PREPARING THE SAME AND ITS USE | Herberts Gesellschaft mit beschränkter Haftung (DE) | 1994-02-17 | — | — | WO | disclosed |
| EP-0581211-A1 | Aqueous coating, process for its preparation and its use in processes for multilayer coating | Herberts Gesellschaft mit beschränkter Haftung (DE) | 1994-02-02 | — | — | EP | disclosed |
| EP-0438090-A1 | Binder composition for the preparation of pigment pastes and aqueous coating compositions containing these pigment pastes | Herberts Gesellschaft mit beschränkter Haftung (DE) | 1991-07-24 | — | — | EP | disclosed |