Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.66 |
| ▸ | HNF4A | P41235 | 5/20 | 0.66 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.53 |
| ▸ | RXRB | P28702 | 4/20 | 0.52 |
| ▸ | RARB | P10826 | 9/20 | 0.51 |
| ▸ | RARG | P13631 | 8/20 | 0.51 |
| ▸ | RARA | P10276 | 7/20 | 0.51 |
| ▸ | RXRG | P48443 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239245 | 0.92 | RXRA (0.77) | RXRAHNF4ACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL6244597 | 0.88 | RXRA (0.86) | RXRAHNF4ACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL6240675 | 0.85 | RXRA (0.68) | RXRAHNF4ACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL6240733 | 0.80 | RXRA (1.00) | RXRAHNF4ACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL6239260 | 0.77 | RXRA (0.78) | RXRAHNF4ACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL6242405 | 0.77 | RXRA (0.61) | RXRAHNF4ACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL9519749 | 0.77 | RXRA (0.71) | RXRACYP26A1CYP3A4CYP26B1RXRB | |
| SCHEMBL6240672 | 0.71 | RXRA (0.58) | RXRAHNF4ACYP26A1CYP3A4CYP26B1 | |
| SCHEMBL6239241 | 0.71 | RARG (0.59) | RXRAHNF4ARXRBRARBRARG | |
| SCHEMBL6242235 | 0.70 | RXRA (0.83) | RXRAHNF4ACYP26A1CYP3A4RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | disclosed |