Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.57 |
| ▸ | CDK4 | P11802 | 6/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.50 |
| ▸ | IKBKB | O14920 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | DKK1 | O94907 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 4/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.42 |
| ▸ | CDK9 | P50750 | 3/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK7 | P50613 | 2/20 | 0.42 |
| ▸ | CCNH | P51946 | 2/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6242590 | 0.85 | CDK2 (0.71) | CDK2CDK4CCNE1IKBKBCDK1 | |
| SCHEMBL6245628 | 0.84 | CDK2 (0.69) | CDK2CDK4CCNE1GSK3BCDK1 | |
| SCHEMBL7978098 | 0.82 | CDK2 (0.57) | CDK2CDK4CCNE1IKBKBGSK3B | |
| SCHEMBL6596039 | 0.80 | CDK2 (0.72) | CDK2CDK4CCNE1IKBKBGSK3B | |
| SCHEMBL700061 | 0.80 | CAMK2D (0.54) | CDK2CDK4CCNE1GSK3BCDK1 | |
| SCHEMBL7978102 | 0.80 | CDK2 (0.50) | CDK2CDK4CCNE1GSK3BCDK1 | |
| SCHEMBL4826639 | 0.78 | CDK2 (0.57) | CDK2CDK4CCNE1GSK3BCDK1 | |
| SCHEMBL4824463 | 0.78 | CDK2 (0.58) | CDK2CDK4CCNE1IKBKBGSK3B | |
| SCHEMBL10285690 | 0.76 | CDK2 (0.46) | CDK2CDK4CCNE1GSK3BCDK1 | |
| SCHEMBL4146725 | 0.75 | ABL1 (0.66) | IKBKBGSK3BDKK1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362050-B1 | PYRIMIDINE DERIVATIVES FOR INHIBITION OF CELL-PROLIFERATION | ASTRAZENECA AB (SE) | 2005-02-02 | — | — | EP | claimed |