Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 3/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | CETP | P11597 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3920913 | 0.81 | ESR2 (0.50) | SMN1; SMN2NPC1RAB9AALDH1A1PTPN1 | |
| SCHEMBL6218707 | 0.78 | MTNR1A (0.46) | CETPALDH1A1PTPN1DHODHKDM4E | |
| SCHEMBL3924017 | 0.78 | PPARD (0.68) | PPARDPPARGPPARA | |
| SCHEMBL13868064 | 0.77 | PPARD (0.51) | PPARDPPARGCETPPPARA | |
| SCHEMBL18951247 | 0.74 | PTPN2 (0.45) | CETPSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL6216739 | 0.73 | DHODH (0.72) | PPARDTP53MAPTPTPN1DHODH | |
| SCHEMBL11817024 | 0.71 | ELANE (0.71) | SMN1; SMN2TP53NPC1RAB9AALDH1A1 | |
| SCHEMBL3918029 | 0.70 | PPARA (0.57) | PPARDPPARGPPARATP53MAPT | |
| SCHEMBL6249086 | 0.70 | PPARD (0.45) | PPARDPPARGPPARAFFAR1FFAR4 | |
| SCHEMBL27636490 | 0.70 | TP53 (0.56) | PPARDPPARGPPARATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585726-A1 | FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063155-A1 | FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |