SCHEMBL624437

SCHEMBL624437

Fc1ccc(Br)c(C(F)(F)F)c1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 3/20 0.46
NOTUM Q6P988 2/20 0.43
MAPT P10636 3/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41
LMNA P02545 2/20 0.41
XBP1 P17861 1/20 0.41
HTT P42858 2/20 0.39
EPHX1 P07099 2/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
TAS2R14 Q9NYV8 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
PDE3B Q13370 1/20 0.37
PDE3A Q14432 1/20 0.37
ALKBH5 Q6P6C2 1/20 0.37
TRPA1 O75762 1/20 0.36
TMPRSS4 Q9NRS4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29572164 1.00 IDO1 (0.46) IDO1NOTUMMAPTMEN1KMT2A
SCHEMBL30133804 0.82 NR3C1 (0.36) IDO1NOTUMMAPTMEN1KMT2A
SCHEMBL19693724 0.82 NR3C1 (0.36) IDO1NOTUMMAPTMEN1KMT2A
SCHEMBL15974121 0.82 NR3C1 (0.36) IDO1NOTUMMAPTMEN1KMT2A
SCHEMBL29519382 0.82 NR3C1 (0.36) IDO1NOTUMMAPTMEN1KMT2A
SCHEMBL457729 0.81 NOTUM (0.46) IDO1NOTUMTRPA1
SCHEMBL29775948 0.81 NOTUM (0.46) IDO1NOTUMTRPA1
SCHEMBL278305 0.79 PTGS1 (0.39) IDO1MAPTMEN1KMT2ALMNA
SCHEMBL31373429 0.78 KDM1A (0.48) NOTUMMAPTMEN1KMT2ANPSR1
SCHEMBL31373428 0.78 KDM1A (0.48) NOTUMMAPTMEN1KMT2ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 391 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119080580-B Preparation method of 2-bromo-5-fluorobenzotrifluoride 内蒙古大中实业化工有限公司 2025-02-18 CN claimed
CN-116143581-B Preparation method of 2-bromo-5-fluorobenzotrifluoride 浙江巍华新材料股份有限公司 2025-02-14 CN claimed
CN-116354896-B Technological method for preparing penconazole by continuous flow micro-channel 西安近代化学研究所 2025-01-28 CN claimed
CN-119176784-A Chlorofluoroether bacteria Synthesis process of azole 安徽久易农业股份有限公司 2024-12-24 CN claimed
CN-119161308-A Chlorofluoroether bacteria Synthesis method of azole 安徽久易农业股份有限公司 2024-12-20 CN claimed
CN-119080580-A Preparation method of 2-bromo-5-fluorobenzotrifluoride 内蒙古大中实业化工有限公司 2024-12-06 CN claimed
CN-118638066-A Bactericide chlorofluoroether bacteria Process for preparing azole compounds 江苏乾元生物科技有限公司 2024-09-13 CN claimed
CN-114163294-B Preparation method of 2-bromo-5-fluorobenzotrifluoride 阜新宇泽化工有限公司 2023-12-26 CN claimed
CN-116983821-A Tail gas treatment device for synthesizing 2-bromo-5-fluorobenzotrifluoride 江苏优普生物化学科技股份有限公司 2023-11-03 CN claimed
CN-116354896-A Technological method for preparing penconazole by continuous flow micro-channel 西安近代化学研究所 2023-06-30 CN claimed
CN-102180836-A Method for synthesizing organic compounds NOVARTIS AG 2011-09-14 CN claimed
US-8008504-B2 Process for the synthesis of organic compounds NOVARTIS AG (CH) 2011-08-30 US claimed
EP-2292607-A2 Process for the synthesis of organic compounds Novartis AG (CH) 2011-03-09 EP claimed
EP-2266961-A2 Process for the synthesis of organic compounds Novartis AG (CH) 2010-12-29 EP claimed
US-20100280257-A1 PROCESS FOR THE SYNTHESIS OF ORGANIC COMPOUNDS ABEL STEPHAN 2010-11-04 US claimed
CN-101759597-A Preparation method of 2-trifluoromethyl-4-aminobenzonitrile CHEMSPEC INTERNAT LTD 2010-06-30 CN claimed
US-20080200692-A1 Process For the Synthesis of Organic Compounds NOVARTIS AG (CH) 2008-08-21 US claimed
CN-101189212-A Method for synthesizing organic compounds NOVARTIS AG (CH) 2008-05-28 CN claimed
EP-1896426-A2 PROCESS FOR THE SYNTHESIS OF ORGANIC COMPOUNDS Novartis AG (CH) 2008-03-12 EP claimed
WO-2006135640-A2 PROCESS FOR THE SYNTHESIS OF ORGANIC COMPOUNDS NOVARTIS AG (CH) 2006-12-21 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080200692-A1 Process For the Synthesis of Organic Compounds ODC1, AZI2, NISCH IDO1 529/4885NOTUM 2412/4885MAPT 1352/4885
US-20100280257-A1 PROCESS FOR THE SYNTHESIS OF ORGANIC COMPOUNDS ODC1, AZI2, NISCH IDO1 529/4885NOTUM 2412/4885MAPT 1352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.