Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 14/20 | 0.42 |
| ▸ | ACVR1B | P36896 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BCL9 | O00512 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4332563 | 0.93 | TGFBR1 (0.47) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4342554 | 0.93 | ALDH1A1 (0.42) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4343661 | 0.90 | TGFBR1 (0.48) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4339463 | 0.90 | ALDH1A1 (0.41) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4339432 | 0.85 | TGFBR1 (0.49) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL5200051 | 0.85 | TRPC3 (0.42) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4346463 | 0.85 | ALDH1A1 (0.43) | TGFBR1ACVR1BRIPK2TDP1ALDH1A1 | |
| SCHEMBL4339635 | 0.84 | TGFBR1 (0.52) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL6247053 | 0.82 | TGFBR1 (0.47) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4343582 | 0.80 | TRPC3 (0.42) | TGFBR1ALDH1A1TSHRKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499308-A2 | TRI-SUBSTITUTED HETEROARYLS AND METHODS OF MAKING AND USING THE SAME | BIOGEN, INC. (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003087304-A2 | TRI-SUBSTITUTED HETEROARYLS AND METHODS OF MAKING AND USING THE SAME | BIOGEN, INC. (US) | 2003-10-23 | — | — | WO | disclosed |